Oct 172014
 

Today one of priorities of Federal North-West Medical Research Centre is the work on personalized and translational medicine in the Centre, and in St. Petersburg and Russia. Translational medicine is fast operational transfer of basic research results (mainly in the field of cell and molecular biology and biochemistry) into clinical practice, id est the creation of diagnostic protocol or therapeutic treatment target based on the identified molecular-cellular mechanisms of diseases’ pathogenesis. The personalized medicine aim is the creation of diagnostic algorithms and treatment strategy taking into account patient’s individual (genetic) characteristics. Today these types of clinical practice include molecular diagnostics and pharmacogenetics.

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Apr 162014
 

Cushing's disease is a severe and rather rare endocrine disorder which mainly affects young patients of working age. Development of Cushing's disease is associated with the formation of pituitary adenoma – tumor which releases adrenocorticotropic hormone (ACTH) into the blood in excessive amounts, such tumor is called corticotropinoma.  ACTH normally regulates the adrenal glands which begin to produce cortisol. In case of corticotropinoma ACTH production increases and the adrenal glands respond by increasing cortisol secretion.

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Apr 142014
 

One of the most promising and rapidly developing areas of modern pharmacology is smart drug delivery or target drug delivery. Despite all medical advances in modern treatment many drugs have serious side effects associated with their negative impact on the intact tissue. Drugs’ joining to the carriers, and, in fact, to the nanoparticles of different nature, allows the delivery to the target organ. Such mechanism enhances the bioavailability of pharmaceutical form, improving solubility and providing various overcoming barriers to reduce the influence on patient’s organism by acting specifically on the damaged area. An important additional advantage is the ability to create long-acting preparations.

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