History of the school of thought and basic research directions

 

One of the progenitors of modern nanotechnology in Russia is a prominent scientist of the 20th century Valentin Borisovich Aleskovskii who being a rector of the State Technological Institute has organized the Department of Solid State Chemistry in 1967 (now the Department of Nanotechnology). In 1977, Aleskovskii being a rector of the Leningrad State University has founded a similar profile department in there.

He is widely known for his research works on the creation of assembly and chemical synthesis method of solid compounds by molecular layering. After 20 years, this method become well known in many countries as the atomic layer epitaxy. Currently this is one of the main methods for the synthesis of nanomaterials.

Currently, researchers of the Laboratory exploring new approach to improve dosage forms and medical materials based on nanotechnology. In particular, the focus of the investigations is to analyze the toxicity and biocompatibility of nanomaterials, as well as the distribution of nanoparticles in the body. In addition, researchers are actively working to develop new cardioprotective drugs based on active and passive targeted drug delivery to the ischemic tissues.

Researchers of the Laboratory have absorbed the techniques of immobilization of fluorescent labels on the surface of silica and organo-silica nanoparticles and techniques of ligand binding to nanoparticles. In these techniques fluorescein sodium and indocyanine green were used as a fluorescent labels, and annexin V was used as a ligand. Researchers of the Laboratory developed the technique of immobilization of silica nanoparticles by bradykinin and adenosine.

It was shown how carbon, silica, and magnetic nanoparticles, per se or immobilized with fluorescent labels, influence on living organisms based on numerous experiments.