Neuromodulation Research Laboratory

 

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Evgeny Mikhaylov, MD, DSc
Head of Laboratory, Deputy Director of the Institute for Research

Major areas

  • Studying the autonomic nervous regulation in CVD pathogenesis
  • Developing and using new approaches to treat cardiovascular diseases by effect on the autonomic nervous system
  • Developing new methods to treat arrhythmias and HF
  • Carrying out registry and population studies of CVD and mainly rhythm disorders

Major national and international projects

  • “Search for regulation mechanisms of autonomic blood circulation and methods for CVD diagnosis and treatment based on the effect on autonomic nervous system” (2018–2020)
  • “Study of the role of autonomic dysfunction and the possibilities of medication and interventional methods to modulate the activity of the autonomic nervous system in cardiovascular conditions” (2015–2017)
  • ESC EORP Atrial Fibrillation Gen III registry, coordination in Russia (2018–2020)
  • ESC EORP Atrial Fibrillation Ablation Long-Term registry, coordination in Russia (2012–2016)
  • Development and coordination of the National Atrial Fibrillation Cryoballoon Ablation Registry (2016—2020)
  • Development and coordination of the Registry of Atrial Fibrillation (AF) Ablation with the Ablation Index (AI) technology (2019–2022)
  • Coordination in Russia of the EPILOGUE study (Ventricular Tachycardia in Ischemic Cardiomyopathy; a Combined Endo-Epicardial Ablation Within the First Procedure Versus a Stepwise Approach)

Grants

  • Russian Foundation for Basic Research #18-315-20050
    “Development of a method for studying the neurogenic regulation of the pulmonary circulation and pulmonary artery remodeling and substantiation of a new treatment method for pulmonary hypertension by selective effect on neural elements” (supervised by E.N. Mikhailov, 2018–2020)
  • Presidential Grant from the Ministry of Science and Higher Education # МД-2314.2020.7 (Contract 075-15-2020-379)
    “Development of methods to improve the quality of medical care using IT and machine learning algorithms for the development of personalized approaches to the management of patients with atrial fibrillation” (supervised by E.N. Mikhailov, 2020–2021)
  • Grant from the Ministry of Science and Higher Education # МК-2330.2020.7 (Contract 075-15-2020-381)
    “Study of the effect of denervation of the trunk and distal branches of the renal arteries on the vascular wall of the arteries and hemodynamics of the pulmonary circulation” (supervised by A. Alieva, 2020–2021)
  • Grant from the Ministry of Science and Higher Education for major research projects (Agreement 075-15-2020-800)
    “Development of new prevention and treatment technologies for heart failure based on neuromodulation” (supervised by E.N. Mikhailov
Major publications

Condori Leandro HI, Vakhrushev AD, Goncharova NS, Korobchenko LE, Koshevaya EG, Mitrofanova LB, Andreeva EM, Moiseeva OM, Lebedev DS, Mikhaylov EN. Stimulation mapping of the pulmonary artery for denervation procedures: an experimental study. J Cardiovasc Transl Res 2020; DOI: 1007/s12265-020-10079-4. IF: 3.312. Access link: https://pubmed.ncbi.nlm.nih.gov/33111219/.

Vakhrushev AD, Condori Leandro HI, Goncharova NS, Korobchenko LE, Mitrofanova LB, Lebedev DS, Mikhaylov EN. Extended renal artery denervation is associated with artery wall lesions, acute systemic and pulmonary hemodynamic changes: a sham-controlled experimental study. Cardiovascular therapeutics 2020; 2020; Article ID 8859663. DOI: 10.1155/2020/8859663. IF: 2.538. Access link: https://pubmed.ncbi.nlm.nih.gov/33193811/.

Kuck KH, Lebedev DS, Mikhaylov EN, Romanov A, Gellér L, Kalējs O, Neumann T, Davtyan K, On YK, Popov S, Bongiorni MG, Schlüter M, Willems S, Ouyang F. Catheter ablation or medical therapy to delay progression of atrial fibrillation: the randomised controlled atrial fibrillation progression trial (ATTEST). Europace 2020; DOI: 1093/europace/euaa298. IF: 4.045. Access link: https://pubmed.ncbi.nlm.nih.gov/33330909/.

Gasimova NZ, Kolunin GV, Artyukhina EA, Ivanitsky EA, Lebedev DS, Mikhaylov EN. A prospective registry of atrial fibrillation ablation with the ablation index technology: rationale and study design. Cardiology 2020; 145 (11):730-735. doi: 10.1159/000508888. IF: 1.791. Access link: https://pubmed.ncbi.nlm.nih.gov/33040058/.

Mikhaylov EN, Moshonkina TR, Zharova EN, Garkina SV, Kovzelev PD, Belyaeva NN, Kozlenok AV, Lebedev DS, Shlyakhto EV. Acute cardiovascular effects of non-invasive electrical spinal cord stimulation: results from a pilot study in humans. J Cardiovasc Transl Res 2020; 13 (6):891-893. doi: 10.1007/s12265-020-10014-7. IF: 3.312. Access link: https://pubmed.ncbi.nlm.nih.gov/32378161/.

Goncharova NS, Moiseeva OM, Condori Leandro HI, Zlobina IS, Berezina AV, Malikov KN, Tashkhanov DM, Lebedev DS, Mikhaylov EN. Electrical stimulation-guided approach to pulmonary artery catheter ablation in patients with idiopathic pulmonary arterial hypertension: a pilot feasibility study with a 12-month follow-up. BioMed Research International 2020; Article ID 8919515, 7 pages; DOI: 10.1155/2020/8919515. IF: 2.276. Access link: https://pubmed.ncbi.nlm.nih.gov/32149144/.

Shkolnikova MA, Jdanov DA, Ildarova RA, Shcherbakova NV, Polyakova EB, Mikhaylov EN, Shalnova SA, Shkolnikov VM. Atrial fibrillation among Russian men and women aged 55 years and older: prevalence, mortality, and associations with biomarkers in a population-based study. J Geriatr Cadiol 2020; 17: 74-84. doi:10.11909/j.issn.1671—5411.2020.02.002. IF: 2.491. Access link: https://pubmed.ncbi.nlm.nih.gov/32165880/.

Condori Leandro HI, Lebedev DS, Mikhaylov EN. Discrimination of ventricular tachycardia and localization of its exit site using surface electrocardiography. J Geriatric Cardiology 2019; 16 (4):362-377. 10.11909/j.issn.1671—5411.2019.04.008. IF: 2.491. Access link: https://pubmed.ncbi.nlm.nih.gov/31105757/.

Korkosh VS, Kisilev AM, Mikhaylov EN, Kostareva AA, Zhorov BS. Atomic mechanisms of Timothy syndrome-associated mutations in calcium channel Cav1.2. Frontiers in physiology 2019; 10:335. doi: 10.3389/fphys.2019.00335. IF: 3.394. Access link: https://pubmed.ncbi.nlm.nih.gov/30984024/.

GloverBM, HongKL, DagresN, ArbeloE, LarocheC, RiahiS, BertiniM, Mikhaylov EN, GalvinJ, KiliszekM, MaggioniAP, Pokushalov E, Kautzner J, Tavazzi L, Blomström Lundqvist C, Brugada J. The impact of body mass index on the outcome of catheter ablation of atrial fibrillation: An analysis from the Atrial Fibrillation Ablation Long-Term Registry conducted by the EURObservational Research Programme of the European Society of Cardiology. Heart 2019; 105 (3):244-250. IF: 5.213. Access link: https://pubmed.ncbi.nlm.nih.gov/30279268/.

Vander MA, Fedotov PA, Lubimtsevaana TA, Bortsova MA, Sitnikova MYu, Lebedev DS, Mikhaylov EN. Renal artery denervation suppresses intractable ventricular arrhythmia in patients with left heart thrombosis. J Geriatr Cardiol 2017; 14: 587-589. IF: 2.491. Access link: https://pubmed.ncbi.nlm.nih.gov/29056958/.

Mikhaylov EN, Lebedev DS, Pokushalov EA, Davtyan KV, Ivanitskii EA, Nechepurenko AA, Kosonogov AYa, Kolunin GV, Morozov IA, Termosesov SA, Maykov EB, Khomutinin DN, Eremin SA, Mayorov IM, Romanov AB, Shabanov VV, Shatakhtsyan V, Tsivkovskii V, Revishvili ASh, Shlyakhto EV. Outcomes of cryoballoon ablation in high- and low-volume atrial fibrillation ablation centres: a Russian pilot survey. Biomed Res Int 2015; vol. 2015, Article ID 591603, 8 pages, 2015. doi:10.1155/2015/591603. IF : 2.276. Access link: https://pubmed.ncbi.nlm.nih.gov/26640789/.

Mikhaylov EN, Lebedev DS, Shlyakhto EV. Ventricular tachycardia ablation after post-infarction ventricular septal defect occluder placement. Europace 2015; 17 (8):1275. IF: 4.045. Access link: https://pubmed.ncbi.nlm.nih.gov/25917025/.

Mikhaylov EN, Mitrofanova LB, Vander MA, Tatarskiy RB, Kamenev AV, Abramov ML, Szili-Torok T, Lebedev DS. Biatrial tachycardia following linear anterior wall ablation for the perimitral reentry: incidence and electrophysiological evaluations. J Cardiovasc Electrophysiol. 2015 Jan;26 (1):28-35. IF: 3.234. Access link: https://pubmed.ncbi.nlm.nih.gov/25215599/.

Michowitz Y, Rahkovich M, Oral H, Zado ES, Tilz R, John S, Denis A, Di Biase L, Winkle RA, Mikhaylov EN, Ruskin JN, Yao Y, Josephson ME, Tanner H, Miller JM, Champagne J, Della Bella P, Kumagai K, Defaye P, Luria D, Lebedev DS, Natale A, Jais P, Hindricks G, Kuck KH, Marchlinski FE, Morady F, Belhassen B. Effects of sex on the incidence of cardiac tamponade following catheter ablation of atrial fibrillation: results from a worldwide survey in 34,943 AF ablation procedures. Circ Arrhythm Electrophysiol 2014 Apr 1;7 (2):274-80. IF: 4.393. Access link: https://pubmed.ncbi.nlm.nih.gov/24519888/.

Mikhaylov EN, Bhagwandien R, Janse P, Theuns DA, Szili-Torok T. Regular atrial tachycardias developing after cryoballoon pulmonary vein isolation: incidence, characteristics and predictors. Europace 2013;15:1710—1717. IF: 4.045. Access link: https://pubmed.ncbi.nlm.nih.gov/23689485/.

Mikhaylov EN, Orshanskaya VS, Lebedev AD, Szili-Torok T, Lebedev DS. Catheter ablation of paroxysmal atrial fibrillation in patients with previous amiodarone-induced hyperthyroidism: a case-control study. J Cardiovasc Electrophysiol 2013;24 (8):888-893. IF: 3.475. Access link: https://pubmed.ncbi.nlm.nih.gov/23574390/

Mikhaylov E.N., Moshonkina T.R., Zharova E.N., Garkina S.V., Kovzelev P.D., Belyaeva N.N., Kozlenok A.V., Lebedev D.S., Shlyakhto E.V. Аcute cardiovascular effects of non-invasive electrical spinal cord stimulation: results from a pilot study in humans. Journal of Cardiovascular Translational Research. 2020. № б/н. С. 1-3. IF 1,143. Access link: https://pubmed.ncbi.nlm.nih.gov/32378161/.

Kiselev A.M., Vaz R., Knyazeva A., Sergushichev A., Dmitrieva R.I., Khudyakov A.A., Jorholt J., Smolina N.A., Sukhareva K., Fomicheva Yu., Mikhailov E.N., Mitrofanova L.B., Predeus A., Sjoberg G., Rudenko D.I., Sejersen T., Lindstrand A., Kostareva A.A. Truncating variant in myof gene is associated with limb-girdle type muscular dystrophy and cardiomyopathy. Frontiers in genetics. 2019. Т. 10. № JUN. С. 608. IF 3,789.
Access link: https://pubmed.ncbi.nlm.nih.gov/31297131/.

Patents and inventions

Database registration certificate No. 2020620748
AF Ablation Database – registry of patients after radiofrequency ablation of pulmonary vein ostia
Authors: Gasymova N., Mikhailov E., Lebedev D.

Patent No. 2649506 dated 04/03/2018
“Method for determining left atrial electroanatomical substrate by high-density contact mapping to stratify the risk of recurrent atrial fibrillation after circular pulmonary vein isolation in patients with paroxysmal and persistent atrial fibrillation”
Authors: Orshanskaya V., Belyakova L., Kamenev A., Mikhailov E., Moiseeva O., Lebedev D.

Patent of invention RF 2355299
“Method for choosing the interventional treatment of paroxysmal AF”
Authors: Mikhailov E., Lebedev D., Tikhonenko V.

Patent of invention RF 2364370
“Method for interventional treatment of paroxysmal AF”
Authors: Lebedev D., Mikhailov E., Mitrofanova L.

Patent of invention RU 2364370 C1 issued on 20.08.2009, application No. 2007142941/14 dated 20.11.2007
“Method for interventional treatment of paroxysmal atrial fibrillation”
Authors: Lebedev D., Mikhailov E., Mitrofanova L., Gureev S.

Patent of invention RU 2355299 C2 issued on 20.05.2009, application No. 2007126114/14 dated 09.07.2007
“Method for choosing the tactics of interventional treatment for paroxysmal atrial fibrillation”
Authors: Lebedev D., Mikhailov E., Tikhonenko V.