Electrocardiology Research Laboratory

 

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Tatyana Treshkur, MD, PhD
Head of Laboratory

Научные направления

  • Non-invasive diagnostic methods in patients with ventricular arrhythmias
  • Non-invasive diagnostic methods for atrial fibrillation (stress testing, Holter monitoring with data telemetry via Internet)
  • Non-invasive electrocardiographic imaging (ECGI)
  • Risk stratification for sudden cardiac death

Results and achievements

Over the past 10 years, the laboratory has tripled its staff and its specialists have made more than 300 scientific publications, have given over 500 lectures during the advanced training course in cardiology and functional diagnostics, hundreds of doctors have been trained, 5 books and several handbooks have been written and published.

The Laboratory specialists consult the outpatients with cardiac arrhythmias at the Diagnostic Department of Almazov Centre, and the patients are included both in the research and in regular medical check-up.

The specialists of the Laboratory have analyzed more than 20,000 ECGs and Holter recordings, gave presentations and presented posters in many Russian cities and in other countries around the world, adopted 10 new medical technologies, 2 inventions, grants, and innovations. Constant training is provided to residents and senior researchers.

Participation in State Assignments

Since 2018, the Research Department has been developing the topic «Diagnostic techniques and effectiveness assessment in socially significant diseases therapy by multicomponent microanalysis of exhaled air» (supervised by Berezina A.).

Since 2020, the Department specialists have started a new topic of the state assignment “Centre for remote monitoring of physiological parameters of a high-risk CVD patient and personalized decision-making algorithms based on real-time data” (supervised by Treshkur T.).

Personal achievements

Treshkur T.

  • Winner of the III National Prize in Cardiology «Purple Heart» in the nomination «Best cardiological project of the year», sub-nomination «Educational project 2011», the project «Educational programme: advanced training cycle in Clinical Cardiology with in-depth study and CVD functional diagnostic methods”, May 19, 2011

Chmelevsky M.

  • Winner of Youth Scientific and Practical Competition 2011, the project „Improving of non-invasive computational cardiac mapping for topical diagnosis of ventricular arrhythmias“
  • Winner of scientific paper competition of the X International Conference on Cardiac Pacing and Clinical Electrophysiology „Cardiostim-2012“
  • Winner of scientific paper competition of the IV Annual Scientific and Practical Conference of Young Scientists and Specialists in the Best Presentation nomination (2012)
  • Winner of the St. Petersburg grant competition for students, graduates and young scientists, topic „Localization diagnosis of polymorphic ventricular arrhythmias using non-invasive computational heart mapping“ (2012)

Ilyina D.

  • Winner of the Young Scientists Competition in Cardiology of the XIX Russian National Congress „Human and Medicine“, the project “Anxiolytic drugs for patients with non-coronary ventricular arrhythmias and increased anxiety» (2012).
Major publications

Sabatine M.S., Giugliano R.P., Keech A.C., Honarpour N., Wiviott S.D., Murphy S.A., Kuder J.F., Wang H., Liu T., Wasserman S.M., Sever P.S., Pedersen T.R., Vishnevsky A., Lukyanov Y., Blokhin A., Kostenko V., Shvarts Y., Markov V., Motylev I., Dronov D. et al. Evolocumab and clinical outcomes in patients with cardiovascular disease. New England Journal of Medicine. 2017. Т. 376. № 18. С. 1713—1722. IF 74,669. Режим доступа: https://pubmed.ncbi.nlm.nih.gov/28304224/.

Bhatt D.L., Steg P.G., Fox K., Ray K.K., Mehta S.R., Leiter L.A., Simon T., Held C., Andersson M., Himmelmann A., Ridderstråle W., Chen J., Song Y., Diaz R., Goto S., James S.K., Parkhomenko A.N., Kosiborod M.N., McGuire D.K., Harrington R.A. et al. Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (themis-pci): a phase 3, placebo-controlled, randomised trial. The Lancet. 2019. Т. 394. № 10204. С. 1169—1180. IF 60,392. Режим доступа: https://www.thelancet.com/journals/lancet/article/PIIS0140—6736 (19) 31887-2/fulltext.

Sohns C., Metzner A., Kuck K. -H., Chmelevsky M. A new algorithm to visualize the individual relationship between electrical rotors from non-invasive panoramic mapping and atrial fibrosis to guide ablation of persistent atrial fibrillation. Clinical Research in Cardiology. 2018. Т. 107. № 5. С. 444-446. IF 4,455. Режим доступа: https://pubmed.ncbi.nlm.nih.gov/29302740/.

Sohns Ch., Lemes Ch., Metzner A., Fink T., Chmelevsky M., Maurer T., Budanova M., Solntsev V., Schulze W., Staab W., Mathew Sh., Heeger Ch., Reißmann B., Kholmovski E., Kivelitz D., Ouyang F., Kuck K.H. First-in-man analysis of the relationship between electrical rotors from noninvasive panoramic mapping and atrial fibrosis from magnetic resonance imaging in patients with persistent atrial fibrillation. Circulation: Arrhythmia and Electrophysiology. 2017. Т. 10. № 8. С. e004419. IF 4,39. Режим доступа: https://pubmed.ncbi.nlm.nih.gov/28790104/.

Potyagaylo D., Chmelevsky M.P., van Dam P., Budanova M.A., Zubarev S.V., Treshkur T.V., Lebedev D.S. ECG adapted fastest route algorithm to localize the ectopic excitation origin in crt patients. Frontiers in Physiology. 2019. Т. 10. № MAR. С. 183. IF 4,134. Режим доступа: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421262/.

Wissner E., Revishvili A., Metzner A., Tsyganov A., Kalinin V., Lemes Ch., Saguner A.M., Maurer T., Deiss S., Sopov O., Labarkava E., Chmelevsky M., Kuck K.H. Noninvasive epicardial and endocardial mapping of premature ventricular contractions. Europace. 2017. Т. 19. № 5. С. 843-849. IF 4,045. Режим доступа: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437699/.

Tsyganov A., Wissner E., Metzner A., Mironovich S., Chaykovskaya M., Kalinin V., Chmelevsky M., Lemes Ch., Kuck K.H. Mapping of ventricular arrhythmias using a novel noninvasive epicardial and endocardial electrophysiology system. Journal of Electrocardiology. 2018. Т. 51. № 1. С. 92-98. IF 1,363. Режим доступа: https://www.sciencedirect.com/science/article/pii/S0022073617302388.

Azpilicueta J., Chmelevsky M., Potyagaylo D. ECGI in atrial fibrillation: a clinicians wish list . Journal of Electrocardiology. 2018. Т. 51. № S6. С. S88-S91. IF 1,363. Режим доступа: https://www.sciencedirect.com/science/article/pii/S0022073618304394.

Parreira L., Carmo P., Adragão P., Pinho J., Budanova M., Zubarev S., Cavaco D., Marinheiro R., Carmo J., Costa F., Marques H., Goncalves P. Non-invasive electrocardiographic imaging in patients with idiopathic premature ventricular contractions from the right ventricular outflow tract: new insights into arrhythmia substrate. Journal of Electrocardiology. 2019. Т. 57. С. 69-76. IF 1,363. Режим доступа: https://pubmed.ncbi.nlm.nih.gov/31514015/.

Potyagaylo D., Chmelevsky M., Budanova M., Zubarev S., Treshkur T., Lebedev D. Combination of lead-field theory with cardiac vector direction: ecg imaging of septal ventricular activation. Journal of Electrocardiology. 2019. Т. 57. № Suppl… С. S40-S44. IF 1,363. Режим доступа: https://www.sciencedirect.com/science/article/pii/S0022073619304509.

Patents and inventions

Patent for invention RU 2611948 issued on 01.03.2017, application No. 2015156622 dated 28.12.2015.
«Method for diagnosing ventricular arrhythmia caused by psycho-emotional factors in patients without structural heart disease»
Authors: Alekseeva D., Treshkur T., Tsurinova E.

Database registration certificate RU 2015620684 issued on 27.04.2015, application No. 2015620205 dated 13.03.2015.
«ICT-FMRC 12-lead long-term arrhythmia database»
Authors: Tikhonenko V., Kozlenok A., Levitin V., Treshkur T., Tulintseva T., Shikhaliev D., Yakushenko E.

Patent for invention RU 2479257 C1 issued on 20.04.2013, application No. 2012105193/14 dated 14.02.2012.
«Method for predicting the effectiveness of myocardial revascularization surgery in CAD patients with high-grade ventricular arrhythmias»
Authors: Tatarinova A., Treshkur T.