Mikhail Galagudza


Prof. Mikhail Galagudza, MD, DSc

Director of the Institute of Experimental Medicine, Chief Researcher, Research Department of Microcirculation and Myocardial Metabolism, Head of Pathology Department, Institute of Medical Education, Professor and Corresponding Member of the Russian Academy of Sciences

H-index (RSCI): 24; 383 publications in RSCI, RSCI Author ID: 112432.

H-index (Scopus): 19; 144 publications (Scopus), Scopus Author ID: 6507925726.

H-index (WOS): 15, 97 publications (WOS), WOS Author ID: C-8479—2011.

ORCID ID: 0000—0001—5129—9944.

Focus areas: mechanisms of myocardial protection against ischemia-reperfusion injury, development of targeted drug delivery using nanocarriers.

2000 – graduated magna cum laude from the Pavlov First Saint Petersburg State Medical University; started a full-time PhD program in the Department of Pathophysiology.

Since 2000 – successively worked at the Department of Pathophysiology of the Pavlov First Saint Petersburg State Medical University as a senior research assistant, assistant, associate professor, professor.

2002 – defended ahead of time his PhD thesis in Pathologic Physiology entitled «Comparative evaluation of the cardioprotective efficacy of local and distant ischemic adaptation of the myocardium» dedicated to myocardial protection against ischemia injury in the experiment.

2003–2004 – long-term academic visit at the Karolinska Institute (Sweden) and the University of Oslo (Norway).

2007 – defended his doctoral thesis on the topic «Pre- and postconditioning as ways to protect the myocardium against ischemia-reperfusion injury»

2007 – Head of Research Laboratory of Myocardial Metabolism, Almazov Federal Heart, Blood and Endocrinology Centre (Almazov National Medical Research Centre).

2009 – present – Director of the Institute of Experimental Medicine, Almazov Centre.

2018 — Head of Pathology Department, Medical Faculty, Institute of Medical Education.

Completed advanced training courses «Rules for the organization and conduct of preclinical studies of drugs – GLP» (2012), «Equipment and organization of a vivarium for small laboratory SPF rodents» (2013).

In 2016, Mikhail Galagudza the title of a Corresponding Member of the Russian Academy of Sciences for scientific contribution to studying of cardiovascular pathophysiology.

Thesis supervision

Seven PhD theses were defended under the scientific advice of Mikhail Galagudza.

Major national and international projects

Supervised state assignments on the following topics:

  • Development of a software and hardware system for remote myocardial conditioning based on local abdominal decompression.
  • Development and optimization of toxicity testing protocol for substances with a molecular weight of more than 3 kDa in fish (Zebra fish).

Training and education

Authored a program in Pathology (specialist degree) at Almazov Centre.

Membership in national and international societies

  • Vice Editor-in-Chief of the Journal of Translational Medicine, member of the editorial board of the journals Regional Blood Circulation and Microcirculation, Bulletin of Experimental Biology and Medicine, Cardiology: News, Opinions, Education.
  • Member of the Board of the Russian Society of Pathophysiology.
Major publications


Model of Chronic Thromboembolic Pulmonary Hypertension in Rats Caused by Repeated Intravenous Administration of Partially Biodegradable Sodium Alginate Microspheres. Karpov A.A., Anikin N.A., Mihailova A.M., Smirnov S.S., Vaulina D.D., Shilenko L.A., Moiseeva O.M., Galagudza M.M., Ivkin D.Yu., Bagrov A.Y. International Journal of Molecular Sciences. 2021. V. 22. № 3. P. 1-18. IF 5,542. DOI: 10.3390/ijms22031149.  https://pubmed.ncbi.nlm.nih.gov/33498971/

Effects of three types of bariatric interventions on myocardial infarct size and vascular function in rats with type 2 diabetes mellitus. Oleg V. Kornyushin, Dmitry L. Sonin, Alexander S. Polozov, Vitaly V. Masley, Maria S. Istomina, Garry V. Papayan, Daria V. Mukhametdinova, Yuri V. Cheburkin, Yana G. Toropova, Irina A. Zelinskaya, Alexander E. Neimark, Kira V. Derkach, Alexander O. Shpakov, Michael M. Galagudza. Life Sciences. 2021. V. 279. P. 1-11. IF 4,659. DOI: 10.1016/j.lfs.2021.119676. https://www.sciencedirect.com/science/article/pii/S0024320521006627

Hemolytic Activity, Cytotoxicity, and Antimicrobial Effects of Human Albumin- and Polysorbate-80-Coated Silver Nanoparticles. Korolev D., Shumilo M., Shulmeyster G., Krutikov A., Golovkin A., Mishanin A., Gorshkov A., Spiridonova A., Domorad A., Krasichkov A., Galagudza M. Nanomaterials. 2021. V. 11. № 6. P. 1-20. IF 4,291. DOI: 10.3390/nano11061484. https://www.mdpi.com/2079—4991/11/6/1484

Comparative evaluation of metformin and liraglutide cardioprotective effect in rats with impaired glucose tolerance. Simanenkova A., Minasian S., Karonova T., Vlasov T., Timkina N., Shpilevaya O., Khalzova A., Shimshilashvili A., Timofeeva V., Samsonov D., Borshchev Y., Galagudza M.  Scientific Reports. 2021. V. 11. № 1. P. 1-12. IF 4,130. DOI: 10.1038/s41598-021-86132-2. https://pubmed.ncbi.nlm.nih.gov/33758265/

Intracellular Development of Resident Cardiac Stem Cells: An Overlooked Phenomenon in Myocardial Self-Renewal and Regeneration. Belostotskaya, G., Sonin, D., Galagudza, M. Life. V. 11. № 8. IF 3,778. DOI: 10.3390/life11080723. https://www.mdpi.com/2075—1729/11/8/723

Association of myocardial and serum miRNA expression patterns with the presence and extent of coronary artery disease: A cross-sectional study.       Polyakova E.A., Zaraiskii M.I., Baranova E.I., Galagudza M.M., Shlyakhto E.V., Mikhaylov E.N. International Journal of Cardiology. 2021. V. 322. P. 9-15. IF 2,276. DOI: 10.1016/j.ijcard.2020.08.043. https://www.sciencedirect.com/science/article/pii/S0167527320335701

Neurohumoral, cardiac and inflammatory markers in the evaluation of heart failure severity and progression. Polyakova E.A., Mikhaylov E.N., Sonin D.L., Cheburkin Y.V., Galagudza M.M. Journal of Geriatric Cardiology. 2021. V. 18. № 1. P. 47-66. IF 1,714. DOI: 10.11909/j.issn.1671—5411.2021.01.007. https://pubmed.ncbi.nlm.nih.gov/33613659/

Modeling of Acute Pulmonary Arterial Hypertension in Pigs Using a Stable Thromboxane A2 Analogue (U46619): Dose Adjustment and Assessment of Hemodynamic Reactions. Goncharova N.S., Andreeva E.M., Moiseeva O.M., Vakhrushev A.D., Leandro H.I.C., Korobchenko L.E., Mikhaylov E.N., Murashova L.A., Voronin S.E., Skorik Y.A., Galagudza M.M., Mitrofanova L.B. Bulletin of Experimental Biology and Medicine. 2021. V. 170. № 6. P. 729-733. IF 0,864. DOI: 10.1007/s10517-021-05142-2. https://pubmed.ncbi.nlm.nih.gov/33893968/


Synthetic Lethality Screening Identifies FDA-Approved Drugs that Overcome ATP7B-Mediated Tolerance of Tumor Cells to Cisplatin. Mariniello M., Petruzzelli R., Wanderlingh L.G., La Montagna R., Carissimo A., Catalano F., Crispino R., Medina D.L., Polishchuk R.S., Pane F., Amoresano A., Ilyechova E.Y., Puchkova L.V., Galagudza M.M.   Cancers. 2020. V. 12. № 3. P. 608. IF 6,102. DOI: 10.3390/cancers12030608. https://pubmed.ncbi.nlm.nih.gov/32155756/

Biological Safety and Biodistribution of Chitosan Nanoparticles. Sonin D., Zhuravskii S., Postnov V., Korolev D., Vasina L., Kostina D., Mukhametdinova D., Zelinskaya I., Skorik Y., Naumysheva E., Malashicheva A., Istomina M., Rubanova N., Aleksandrov I., Vasyutina M., Pochkaeva E., Somov P., Galagudza M. Nanomaterials. 2020. V. 10. № 4. P. 810. IF 4,921. DOI: 10.3390/nano10040810. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221586/

How to Stimulate Myocardial Regeneration in Adult Mammalian Heart: Existing Views and New Approaches. Belostotskaya G., Hendrikx M., Galagudza M., Suchkov S. BioMed Research International. 2020. V. 2020. P. 1-9. IF 3,047. DOI: 10.1155/2020/7874109. https://www.hindawi.com/journals/bmri/2020/7874109/

Antibody against Na/K-ATPase Inhibitor Lowers Blood Pressure and Increases Vascular Fli1 in Experimental Preeclampsia. Agalakova N.I., Nadei O.V., Bagrov A.Y., Reznik V.A., Ershov I.A., Rassokha O.S., Ivanov D.O., Vasyutina M.L., Galagudza M.M., Adair C.D. American Journal of Hypertension. 2020. V. 33. № 6. P. 514-519. IF 1,926. DOI: 10.1093/ajh/hpz180. https://pubmed.ncbi.nlm.nih.gov/31713584/

Perivascular Innervation of the Pulmonary Artery in Human and Swine: A Comparative Study for the Development of an Experimental Model of Denervation. Koshevaya E.G., Mitrofanova L.B., Goncharova N.S., Leandro H.I.C., Vakhrushev A.D., Korobchenko L.E., Murashova L.A., Galagudza M.M., Perminova A.A., Moiseeva O.M., Mikhaylov E.N. Bulletin of Experimental Biology and Medicine. 2020. V. 170. № 2. P. 279-282. IF 0,834. DOI: 10.1007/s10517-020-05051-w.  https://pubmed.ncbi.nlm.nih.gov/33263852/

Acute pulmonary arterial hypertension modeling in swine using a stable thromboxane A2 analogue (U46619): dose adjustment and assessment of hemodynamic reactions. Goncharova N.S., Andreeva E.M., Vakhrushev A.D., Condori Leandro H.I., Murashova L.A., Voronin S.E., Korobchenko L.E., Mitrofanova L.B., Skorik Yu.A., Galagudza M.M., Moiseeva O.M., Mikhaylov E.N. Bulletin of Experimental Biology and Medicine. 2020. V. 170. № 2. P. 279-282. IF 0,834. DOI: 10.47056/0365—9615-2020-170-12-709-714.  https://www.researchgate.net/publication/344777533_Acute_pulmonary_arterial_hypertension_modeling_in_swine_using_a_stable_thromboxane_A2_analogue_U46619_dose_adjustment_and_assessment_of_hemodynamic_reactions

Effect of Combined Antimicrobial Therapy on Ischemia/Reperfusion Myocardial Injury in Rats with Acute Inflammation of the Large Intestine against the Background of Alimentary Obesity. Burovenko I.Y., Borshchev Y.Y., Minasian S.M., Borshchev V.Y., Protsak E.S., Borshcheva O.V., Galagudza M.M. Bulletin of Experimental Biology and Medicine. 2020. V. 168. № 3. P. 309-312. IF 0,834. DOI: 10.1007/s10517-020-04697-w. https://pubmed.ncbi.nlm.nih.gov/31938911/

Mariniello M., Petruzzelli R., Wanderlingh L.G., La Montagna R., Carissimo A., Pane F., Amoresano A., Ilyechova E. Y., Galagudza M. M., Catalano F., Crispino R., Puchkova L. V., Medina D. L., Polishchuk R. S. Synthetic lethality screening identifies FDA-approved drugs that overcome ATP7B-mediated tolerance of tumor cells to cisplatin. Cancers (Basel). 2020;12 (3): ID 608. doi: 10.1007/s00441-019-03130-7.


Borshchev, Y.Y., Uspensky, Y.P., Galagudza, M.M. Pathogenetic pathways of cognitive dysfunction and dementia in metabolic syndrome. Life Sciences. 2019; 237: ID 116932. DOI: 10.1016/j.lfs.2019.116932.

Borshchev, Y.Y., Minasian, S.M., Burovenko, I.Y., Borshchev, V.Y., Protsak, E.S., Semenova, N.Y., Borshcheva, O.V., Galagudza, M.M. Effects of tetracycline on myocardial infarct size in obese rats with chemically-induced colitis. PLoS ONE. 2019; 14 (11), ID e0225185. DOI: 10.1371/journal.pone.0225185.

Baysa, A; Fedorov, A; Kondratov, K; Ruusalepp, A; Minasian, S; Galagudza, M; Popov, M; Kurapeev, D; Yakovlev, A; Valen, G; Kostareva, A; Vaage, J; Stenslokken, KO. Release of Mitochondrial and Nuclear DNA During On-Pump Heart Surgery: Kinetics and Relation to Extracellular Vesicles. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH. 2019; 12 (3): 184-192. DOI: 10.1007/s12265-018-9848-3.

Knyazeva, A; Krutikov, A; Golovkin, A; Mishanin, A; Pavlov, G; Smolina, N; Hushkina, A; Sejersen, T; Sjoberg, G; Galagudza, M; Kostareva, A. Time- and Ventricular-Specific Expression Profiles of Genes Encoding Z-Disk Proteins in Pressure Overload Model of Left Ventricular Hypertrophy. FRONTIERS IN GENETICS. 2019; 9: ID 684  DOI: 10.3389/fgene.2018.00684.


Belostotskaya, G.B., Nerubatskaya, I.V., Galagudza, M.M. Two mechanisms of cardiac stem cell-mediated cardiomyogenesis in the adult mammalian heart include formation of colonies and cell-in-cell structures. 2018; 9 (75):  34159-34175. DOI: 10.3389/fncel.2017.00264.



Уведомляем вас, что в соответствии с Федеральным законом от 06.03.2006 № 35-ФЗ «О противодействии терроризму» в Центре Алмазова введен комплекс дополнительных мер по безопасности, направленный на предотвращение террористических актов. В целях обеспечения безопасности граждан и целостности объектов инфраструктуры при посещении Центра Алмазова проводится дополнительный личный осмотр, осмотр вещей и автотранспорта. Отказ от соблюдения мер по безопасности может послужить причиной недопуска на территорию Центра Алмазова. Просим с пониманием отнестись к введенным мерам по безопасности.

С уважением, Администрация Центра Алмазова