Epidemiology of cardiovascular diseases in 12 regions of Russian Federation (ESSE-RF)


Ministry of Health of the Russian Federation has launched the new study of Epidemiology of cardiovascular diseases in 12 regions of Russian Federation (ESSE-RF) differing in climatic, geographic, economic and demographic characteristics. The aim of the study is to estimate the prevalence and contribution of traditional and new risk factors to cardiovascular morbidity and mortality rates in Russian population.

The aim of study is to study the prevalence of risk factors and cardiovascular diseases in 12 regions of Russia and elaborate the risk model for Russian population, investigate the traditional and new cardiovascular risk factors.

The subjective of study is to analyze prevalence of cardiovascular risk factors, elaboration of model for cardiovascular risk management, searching for new risk factors and monitoring of cardiovascular mortality.

From September 2012 to April 2013 random sampling of 1600 Saint-Petersburg inhabitants stratified by age and sex was selected. All subjects signed informed consent and filled in questionnaire regarding physical activity, smoking, education, concomitant diseases and therapy. Anthropometry (weight, height with body-mass index calculation, waist circumference) and blood pressure measurement (two times on right hand in sitting position with calculation of average level) were performed. Electrocardiography, carotid-femoral pulse wave velocity (SphygmoCor (Atcor, Australia) were assessed. VaSera VS-1500 (Fukuda, Japan) device was used to measure cardio-ankle vascular index (CAVI) and ankle-brachial index (ABI). Fasting lipids, glucose, creatinine, uric acide, microalbuminuria, adipokines (Abbott Architect 8000 (USA), Roche-diagnostics) were performed. Genomic DNA was extracted from blood samples using magnetic bead technology. The TCF7L2 polymorphism rs 1225537 was determined using real time PCR method by allele-specific probes (Applied Biosystems).

The database formation was finished and prospective part of study (after 1 year of follow-up) was just started.