Prof. Olga Moiseeva, MD, DSc

 

Director of Heart and Vessels Institute, Chief Researcher of the Department

H-index (RSCI): 17; 281 publications in RSCI
RSCI Author ID: 166922, WOS Author ID: AAN-1762—2020, Scopus Author ID: 35836770800, ORCID ID: 0000—0002—7817-3847

Focus areas: study of the pathogenesis of inflammatory heart diseases and cardiomyopathies, pulmonary hypertension, acquired valvular and aortic disease, СVD in pregnancy.

1982 – graduated from the Pavlov First Saint Petersburg State Medical University with honors (General Medicine).

1982–1985 – clinical residency at the Faculty Therapy Chair of the Pavlov First Saint Petersburg State Medical University in Internal Medicine.

1985 – till now – working at Almazov Centre.

1992 – defended her PhD thesis on the topic “Active transport of cations and structural/functional properties of blood cells in AH course”

2004 – defended doctoral thesis on the topic “Cellular aspects of myocardial and vascular remodeling in AH”.

Since 2004 – Head of Non-Coronary Heart Disease Research Department of Almazov Centre.

In 2009 – Deputy Director for Research at the Heart and Vessels Institute, since 2018 – Director of the Heart and Vessels Institute.

Major international projects

International projects: Pregnancy and Cardiac Disease (ROPAC), CTEPH Physician Survey and EMEA CTEPH Registry

Participation in Thesis Committees

Member of the Thesis Committee Д 208.054.01 of Almazov Centre in Cardiology and Cardiovascular Surgery.

Thesis supervision

Seven PhD theses were defended under the scientific advice of Professor Moiseeva. Currently, 3 PhD students continue their research under her guidance.

Membership in national and international societies

Member of the Russian Society of Cardiology, the European Society of Cardiology (ESC), the European Heart Failure Association (HFA), the European Respiratory Society (ERS), the Pulmonary Vascular Research Institute (PVRI).

Member of the Expert medical group of the Central Attestation Commission in the Northwestern Federal District.

Expert of the working group of the Scientific Council of the Russian Ministry of Health (scientific platform «Cardiology and Angiology»).

Membership in editorial boards

Member of the editorial boards of peer-reviewed research and practice journals Arterial Hypertension, Translational Medicine and Cardiology: News, Opinions and Training.

Training and education

Professor at the Faculty Therapy Chair of the Pavlov First Saint Petersburg State Medical University

Personal achievements

Olga Moiseeva was awarded the Certificate of Merit of the Russian Ministry of Health for contribution to healthcare and expert work (2015), Diploma of the Chairman of the Committee for Science and Higher Education of the Government of St. Petersburg for scientific potential development (2015) and the Honorary Badge of Excellence in Healthcare (2009).

Major publications

Ghofrani H.A., Simonneau G., Jaïs X., D'Armini A.M., Fedullo P., Kim N.H., Howard L.S., Jenkins D.P., Jing Z.C., Madani M.M., Martin N., Papadakis K., Richard D., Mayer E., Lang I., Kähler C., Delcroix M., Bshouty Z., Varela P.S., Yang Y. et al. Macitentan for the treatment of inoperable chronic thromboembolic pulmonary hypertension (merit-1): results from the multicentre, phase 2, randomised, double-blind, placebo-controlled study.  The Lancet Respiratory Medicine. 2017. Т. 5. № 10. С. 785-794. IF 22,922

Ignatieva E., Kostina D., Irtyuga O., Uspensky V., Golovkin A., Gavriliuk N., Moiseeva O., Kostareva A., Malashicheva A.  Mechanisms of smooth muscle cell differentiation are distinctly altered in thoracic aortic aneurysms associated with bicuspid or tricuspid aortic valves.  Frontiers in Physiology. 2017. Т. 8. № JUL. С. 536. IF 4,134

Irtyuga O.B., Malashicheva A.B., Zhiduleva E.V., Freilikhman O.A., Rotar O.P., Back M., Tarnovskaya S.I., Kostareva A.A., Moiseeva O.M. Notch1 mutations in aortic stenosis: association with osteoprotegerin/rank/rankl. BioMed Research International. 2017. Т. 2017. С. 6917907. IF  2,583

Regitz-Zagrosek V., Bauersachs J., Kintscher U., Kranke P., Seeland U., Hindricks G., Katus H.A., Roos-Hesselink J.W., Pieper P.G., Delgado V., Blomström-Lundqvist C., Cífková R., De Bonis M., Presbitero P., Simoncini T., Barbato E., Piepoli M.F., Iung B., Aboyans V., Collet J.P. et al. 2018 ESC guidelines for the management of cardiovascular diseases during pregnancy. European Heart Journal. 2018. Т. 39. № 34. С. 3165—3241. IF 24,889

Kostina A., Shishkova A., Ignatieva E., Irtyuga O., Bogdanova M., Levchuk K., Golovkin A., Zhiduleva E., Uspenskiy V., Moiseeva O., Kostareva A., Malashicheva A., Faggian G., Vaage J., Rutkovskiy A.  Different notch signaling in cells from calcified bicuspid and tricuspid aortic valves. Journal of Molecular and Cellular Cardiology. 2018. Т. 114. С. 211-219. IF 5,055

Galiè N., Channick R.N., Frantz R.P., Grünig E., Jing Zh.Ch., Moiseeva O.M., Preston I.R., Pulido T., Safdar Z., Tamura Yu., McLaughlin V.V. Risk stratification and medical therapy of pulmonary arterial hypertension. European Respiratory Journal. 2019. Т. 53. № 1. С. 1801889. IF 12,242

Karpov A.A., Puzanov M.V., Docshin P.M., Moiseeva O.M., Anikin N.A., Ivkin D.Y., Krasnova M.V., Galagudza M.M.  Non-inferiority of microencapsulated mesenchymal stem cells to free cells in cardiac repair after myocardial infarction: a rationale for using paracrine factor (s) instead of cells International. Journal of Experimental Pathology. 2019. Т. 100. № 2. С. 102-113. IF 1,706

Kudryavtsev I.V., Serebriakova M., Isakov D., Zhiduleva E., Murtazalieva P., Titov V., Malashicheva A., Shishkova A., Semenova D., Irtyuga O., Moiseeva O., Golovkin A. CD73 rather than cd39 is mainly involved in controlling purinergic signaling in calcified aortic valve disease. Frontiers in genetics. 2019. Т. 10. № JUN. С. 604. IF 3,517

Patents

Patent RU 2357250 C1, 27.05.2009, application No.2007145813/15 dated 10.12.2007
«Method for prediction of CHF course»
Authors: Karelkina E., Moiseeva O.

Patent RU 2357258 C1, 27.05.2009, application No. 2007142942/15 dated 20.11.2007
«Method for prediction of the regression from left ventricular myocardial hypertrophy in patients with aortic stenosis after aortic valve replacement»
Authors: Moiseeva O., Goncharova N.

Patent RU 2341801 C2, 20.12.2008, application No. 2006142168/15 dated 28.11.2006.
«Method for evaluating the effectiveness of antihypertensive therapy in AH patients»
Authors: Moiseeva O., Novoselov S., Margulis B., Guzhova I.

Patent RU 2649506 C1, 03.04.2018, application No. 2016147662 dated 06.12.2016.
«Method for determination of the electroanatomical substrate in contact mapping of high density of the endocardial surface of the left atrium to stratify the risk of recurrent AF after circular isolation of pulmonary veins in patients with paroxysmal and persistent AF»
Authors: Orshanskaya V., Belyakova L., Kamenev A., Mikhailov E., Moiseeva O., Lebedev D.

Patent RU 2618435 C1, 03.05.2017, application No. 2016114809 dated 15.04.2016
«Method for microencapsulation of stem cells»
Authors: Karpov A., Puzanov M., Almukhametova F., Lomakina A., Cherepanov D., Moiseeva O., Galagudza M.

Patent RU 2716455 C1, 11.03.2020, application No. 2019125445 dated 12.08.2019.
«Method for balloon angioplasty of the pulmonary artery branches in CTEPH patients»
Authors: Marukyan N., Simakova M., Moiseeva O., Zverev D., Zubarev D.

Database registration certificate RU 2015620910, 11.06.2015, application No. 2015620240 dated 20.03.2015.
«Registry of patients with varying degrees of severity of aortic stenosis (PAC)»
Authors: Irtyuga O., Murtazalieva P., Zhiduleva E., Kozlenok A., Moiseeva O.

Database registration certificate RU 2016621200, 01.09.2016, application No. 2016620912 dated 05.07.2016.
«Registry of patients with ascending aorta dilatation (PABOA)»
Authors: Irtyuga O., Gordeev M., Kozlenok A., Moiseeva O.

Database registration certificate RU 2018620437, 14.03.2018, application No. 2018620083 dated 16.01.2018.
«Registry of CTEPH patients»
Authors: Simakova M., Marukyan N., Ryzhkov A., Karpova D., Moiseeva O.