Evgeny N. Mikhaylov, MD, PhD, FESC

 

Associate Professor, Deputy Director, Institute of Heart and Vessels, Head, Neuromodulation Research Laboratory, Professor, Department of Cardiovascular Surgery, Institute of Medical Education.

H-index RSCI: 19; Scopus: 13; WoS: 9
ORCID ID: 0000—0002—6553-9141.
Russian electronic library link:  e-library.
Publications in pubmed.
Google scholar.
Researchgate.net.

Research focus areas: electrophysiological, neuro-dependent and structural mechanisms of development and progression of cardiac arrhythmias, heart failure and other cardiovascular system dysfunctions. Interventional treatment of cardiac arrhythmias and heart failure, cardiac pacing. Complex approaches to interventional correction of arrhythmias in structural pathology of the heart. Neuromodulation for the treatment of cardiovascular diseases. Prevention of sudden cardiac death. Observational studies in arrhythmias. Processing and algorithmization of the analysis of electrocardiographic signals. Development of new catheter ablation technologies for the treatment of arrhythmias and denervation, non-invasive methods for correcting blood pressure and heart failure management.

Clinical focus areas: management of cardiac arrhythmias (catheter ablation for complex tachyarrhythmias, especially in severe structural heart diseases; drug therapy), implantation of devices for the correction of cardiac conduction disturbances, treatment of heart failure and prevention of sudden death.

In 2004, he graduated with honors from Pavlov First St. Petersburg State Medical University, specializing in General Medicine. From 2004 to 2005, he took an internship in Internal Medicine.

From 2005 to 2007, he took a residency in Cardiology at Almazov Centre.

Since his student years, he has been involved in the treatment of patients with cardiac arrhythmias and in scientific research on this topic. Since 2002, he has been working at Almazov Centre.

He underwent training and internships in cardiology and arrhythmology in the USA, the Netherlands, and Germany.

In 2008, he defended his PhD thesis in Cardiology.

In 2012, he defended his doctoral thesis in Cardiology and Cardiovascular Surgery on the topic “Improvement and effectiveness evaluation of interventional treatment of atrial fibrillation”.

Since 2014, he has been the head of the Neuromodulation Research Laboratory as part of the Arrhythmology Department.

Under the mentorship of Evgeny Mikhaylov three PhD theses have been successfully defended by 2021; the research continues in several promising directions.

A number of scientific clinical and experimental studies are underway, new approaches and methods of interventional treatment of cardiovascular diseases are being developed. Research studies of PhD students and co-workers have been repeatedly awarded professional prizes: the prize of the Russian Society of Cardiology, the All-Russian Scientific Society of Arrhythmology, the Committee for Science and Higher Education of St. Petersburg.

Membership in national and international professional societies

Member of the Russian Society of Cardiology.

Fellow of the European Society of Cardiology (FESC).

Member of the Presidium of the All-Russian Scientific Society of Arrhythmology.

Member of the European Heart Rhythm Association (EHRA).

National Ambassador, Young Electrophysiologists of the European Heart Rhythm Association (Young EP EHRA, 2018—2020).

Participation in the development of clinical practice guidelines

Russian Society of Cardiology guidelines, approved by the Russian Ministry of Health:

  • 2020 Ventricular rhythm disorders, ventricular tachycardias and sudden cardiac death.
  • 2020 Bradiarrhythmias and conductivity disorders.
  • 2020 Supraventricular tachycardias in adults.
  • 2020 Atrial fibrillation and atrial flutter.

European Society of Cardiology guidelines (member of the group of reviewers representing national professional societies):

  • 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS).
  • 2019 ESC Guidelines for the management of patients with supraventricular tachycardia.
  • 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS.
  • 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death.

Participation in major national and international projects

Large scientific project “Development of new technologies for the prevention and treatment of heart failure based on neuromodulation” with the support from the Russian Ministry of Education and Science (agreement No. 075-15-200-800).

Prospective registry of catheter ablation of atrial fibrillation using the “Ablation Index” technology.

National prospective registry for cryoballoon ablation of atrial fibrillation.

ESC EORP atrial fibrillation III registry.

BERLIN-VT: early ablation of ischemic ventricular tachycardia.

ATTEST, atrial fibrillation progression trial.

ESC EORP atrial fibrillation ablation long-term registry.

RE-CIRCUIT, anticoagulation in atrial fibrillation catheter ablation.

EPILOGUE, combimed endo-epicardial catheter ablation of ventricular tachycardia versus stepwise approach.

Dissertation Council

Member of Dissertation Council No. 21.1.028.02 at Almazov Centre in Cardiology and Cardiovascular Surgery.

Membership in editorial boards of scientific journals

Journal of Geriatric Cardiology, Editorial Board member.

Journal of Arrhythmology, Deputy Editor.

Russian Journal of Cardiology, Editorial Board member.

Translational Medicine, Editorial Board member.

Personal achievements

2020 — Certificate of Acknowledgment from the Chairman of the Russian Federation Council

2017 — Certificate of Acknowledgment from the Russian Ministry of Health

2011 — ranked 1st in the research competition of the All-Russian Scientific Society of Arrhythmology

2010 – Award of the St. Petersburg Health Committee for Excellence in Healthcare

Selected publications

2021

Transcatheter radiofrequency pulmonary artery denervation in swine: the evaluation of lesion degree, hemodynamics and pulmonary hypertension inducibility. Goncharova NS, Condori Leandro HI, Vakhrushev AD, Koshevaya EG, Skorik YA, Mitrofanova LB, Murashova LA, Korobchenko LE, Andreeva EM, Lebedev DS, Moiseeva OM, Mikhaylov EN. BMC Pulm Med. 2021 Dec 18;21 (1):418. doi: 10.1186/s12890-021-01786-y.PMID: 34922518

An Ovine Model for Percutaneous Pulmonary Artery Laser Denervation: Perivascular Innervation and Ablation Lesion Characteristics. Condori Leandro HI, Koshevaya EG, Mitrofanova LB, Vakhrushev AD, Goncharova NS, Korobchenko LE, Andreeva EM, Lebedev DS, Mikhaylov EN. Int J Mol Sci. 2021 Aug 16;22 (16):8788. doi: 10.3390/ijms22168788.PMID: 34445490

Catheter ablation or medical therapy to delay progression of atrial fibrillation: the randomized controlled atrial fibrillation progression trial (ATTEST). Kuck KH, Lebedev DS, Mikhaylov EN, Romanov A, Gellér L, Kalējs O, Neumann T, Davtyan K, On YK, Popov S, Bongiorni MG, Schlüter M, Willems S, Ouyang F. Europace. 2021 Mar 8;23 (3):362-369. doi: 10.1093/europace/euaa298.PMID: 33330909

Stimulation Mapping of the Pulmonary Artery for Denervation Procedures: an Experimental Study.

Condori Leandro HI, Vakhrushev AD, Goncharova NS, Korobchenko LE, Koshevaya EG, Mitrofanova LB, Andreeva EM, Moiseeva OM, Lebedev DS, Mikhaylov EN. J Cardiovasc Transl Res. 2021 Jun;14 (3):546-555. doi: 10.1007/s12265-020-10079-4. Epub 2020 Oct 27.PMID: 33111219

Reprocessing of electrophysiology material in EHRA countries: an EHRA Young EP survey. Duncker D, Svetlosak M, Guerra F, Nagy KV, Vanduynhoven P, Mikhaylov EN, Kosiuk J. Europace. 2021 Mar 8;23 (3):479-485. doi: 10.1093/europace/euaa250.PMID: 33083819

2020

A Prospective Registry of Atrial Fibrillation Ablation with the Ablation Index Technology: Rationale and Study Design. Gasimova NZ, Kolunin GV, Artyukhina EA, Ivanitsky EA, Lebedev DS, Mikhaylov EN. Cardiology. 2020;145 (11):730-735. doi: 10.1159/000508888. Epub 2020 Oct 9.PMID: 33040058

Acute Cardiovascular Effects of Non-Invasive Electrical Spinal Cord Stimulation: Results from a Pilot Study in Humans. Mikhaylov EN, Moshonkina TR, Zharova EN, Garkina SV, Kovzelev PD, Belyaeva NN, Kozlenok AV, Lebedev DS, Shlyakhto EV. J Cardiovasc Transl Res. 2020 Dec;13 (6):891-893. doi: 10.1007/s12265-020-10014-7. Epub 2020 May 6.PMID: 32378161

Atrial fibrillation among Russian men and women aged 55 years and older: prevalence, mortality, and associations with biomarkers in a population-based study. Shkolnikova MA, Jdanov DA, Ildarova RA, Shcherbakova NV, Polyakova EB, Mikhaylov EN, Shalnova SA, Shkolnikov VM. J Geriatr Cardiol. 2020 Feb;17 (2):74-84. doi: 10.11909/j.issn.1671—5411.2020.02.002.PMID: 32165880

Electrical Stimulation-Guided Approach to Pulmonary Artery Catheter Ablation in Patients with Idiopathic Pulmonary Arterial Hypertension: A Pilot Feasibility Study with a 12-Month Follow-Up. Goncharova NS, Moiseeva OM, Condori Leandro HI, Zlobina IS, Berezina AV, Malikov KN, Tashkhanov DM, Lebedev DS, Mikhaylov EN.Biomed Res Int. 2020 Feb 17;2020:8919515. doi: 10.1155/2020/8919515.

2019

Discrimination of ventricular tachycardia and localization of its exit site using surface electrocardiography. Condori Leandro HI, Lebedev DS, Mikhaylov EN. J Geriatr Cardiol. 2019 Apr;16 (4):362-377. doi: 10.11909/j.issn.1671—5411.2019.04.008.PMID: 31105757

2015

Outcomes of Cryoballoon Ablation in High- and Low-Volume Atrial Fibrillation Ablation Centres: A Russian Pilot Survey. Mikhaylov EN, Lebedev DS, Pokushalov EA, Davtyan KV, Ivanitskii EA, Nechepurenko AA, Kosonogov AY, Kolunin GV, Morozov IA, Termosesov SA, Maykov EB, Khomutinin DN, Eremin SA, Mayorov IM, Romanov AB, Shabanov VV, Shatakhtsyan V, Tsivkovskii V, Revishvili ASh, Shlyakhto EV. Biomed Res Int. 2015;2015:591603. doi: 10.1155/2015/591603. Epub 2015 Nov 12.PMID: 26640789

Biatrial tachycardia following linear anterior wall ablation for the perimitral reentry: incidence and electrophysiological evaluations. Mikhaylov EN, Mitrofanova LB, Vander MA, Tatarskiy RB, Kamenev AV, Abramov ML, Szili-Torok T, Lebedev DS. J Cardiovasc Electrophysiol. 2015 Jan;26 (1):28-35. doi: 10.1111/jce.12543. Epub 2014 Oct 20.PMID: 25215599

2013

Catheter ablation of paroxysmal atrial fibrillation in patients with previous amiodarone-induced hyperthyroidism: a case-control study. Mikhaylov EN, Orshanskaya VS, Lebedev AD, Szili-Torok T, Lebedev DS. J Cardiovasc Electrophysiol. 2013 Aug;24 (8):888-93. doi: 10.1111/jce.12140. Epub 2013 Apr 9.PMID: 23574390

Regular atrial tachycardias developing after cryoballoon pulmonary vein isolation: incidence, characteristics, and predictors.
Mikhaylov EN, Bhagwandien R, Janse PA, Theuns DA, Szili-Torok T.Europace. 2013 Dec;15 (12):1710-7. doi: 10.1093/europace/eut129.

2011

Outcome of anatomic ganglionated plexi ablation to treat paroxysmal atrial fibrillation: a 3-year follow-up study. Mikhaylov E, Kanidieva A, Sviridova N, Abramov M, Gureev S, Szili-Torok T, Lebedev D. Europace. 2011 Mar;13 (3):362-70. doi: 10.1093/europace/euq416. Epub 2010 Nov 17.PMID: 21088001

Selected tutorials:

Management of patients with cardiac arrhythmias. Tutorial. Second edition, corrected and updated. 2021 https://scardio.ru/content/documents/Aritmology_broshura.pdf

Determination of the etiology of ventricular arrhythmias by endomyocardial biopsy. Modern understanding of myocarditis, arrhythmogenic dysplasia/cardiomyopathy of the right ventricle and types of cardiosclerosis. Tutorial. 2015

Catheter ablation of incisional atrial tachycardias. Tutorial. 2015.

Cryoballoon isolation of pulmonary veins. A guide for physicians. 2015

Selected textbooks

Practical guidelines for the procedure of cryoballoon isolation of pulmonary veins, 2020

Arrhythmology: from fundamental research to treatment standards, 2017

Selected aspects of the diagnosis and treatment of arrhythmias and heart failure, 2016