Arrhythmology Research Department

 
Dmitry Lebedev, MD, DSc
Head of Department,
Professor of Surgical Diseases Chair, Professor of RAS

The Research Department comprises:

  • Interventional Arrhythmology Research Laboratory
  • Clinical Arrhythmology Research Laboratory
  • Neuromodulation Research Laboratory

Ongoing research

Fundamental research on the topic: «The study of the molecular, genetic and electrophysiological mechanisms of cardiac arrhythmias and the search for new treatment approaches»:

  • Identifying the genetic and pathophysiological determinants for the development of cardiomyopathies of various origin and congenital arrhythmias (jointly with the Institute of Molecular Biology and Genetics and Pathology Unit).
  • Genetic variants associated with sudden death syndrome, including those with long and short QT interval syndromes, hypertrophic and dilated cardiomyopathies, arrhythmogenic dysplasia, non-compact myocardium (jointly with the Institute of Molecular Biology and Genetics and Pathology Unit).
  • Pathomorphological basis of atrial and ventricular tachyarrhythmias by histological and immunohistochemical analysis of endomyocardial biopsy specimens (jointly with Pathology Unit and Non-Coronary Heart Disease Research Department).
  • Electromechanical coupling of the hibernating myocardium in post-infarction patients through 3D electromechanical mapping.
  • Electrophysiological properties of the cardiac conduction system in chronic ischemia, conduction and endocrine disorders.
  • Electrophysiological mechanisms and predictors for the development of postoperative incisional tachyarrhythmias.
  • Electrophysiological mechanisms of unstable, polymorphic and unmappable tachyarrhythmias in the 3D model of multi-electrode non-contact mapping and surface mapping (jointly with the Research Department for Circulatory Physiology).

Applied research on topics:

  • Improving the interventional and surgical methods for treating atrial fibrillation, ventricular tachycardia and heart failure in adults and children.
  • Studying the pathogenesis of cardiac arrhythmias in adults and children.
  • Optimizing the use of implantable devices for the diagnosis and treatment of arrhythmias

Clinical areas

  • Radio-frequency catheter ablation, including with 3D navigation mapping and robotic navigation
  • Balloon and catheter cryoablation
  • Pacemaker implantation
  • Implantation of cardioverter defibrillators (ICDs)
  • Implantation of cardiac resynchronization devices (CRT)
  • Loop recorder implantation
  • Endomyocardial biopsy (EMB)
  • Programming of implantable devices