Heart Failure Research Department

 

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Prof. Maria Sitnikova, MD, DSc
Head of Department

Heart Failure Research Department was established in 2001, initially as a research laboratory to study the pathogenetic mechanisms and search for new approaches to the treatment of chronic heart failure (CHF). In 2009, it was transformed into research department.

The Research Department comprises:

  • Heart Failure Research Laboratory
  • Research Laboratory of High-Tech Methods

Newly developed and implemented technologies

  • «Differential diagnosis of dyspnea development mechanism»
    Authors: M. Sitnikova, T. Lelyavina, A. Berezina, A. Kozlenok
  • «Optimal tactics for the treatment of elderly CHF patients by their survival assessment»
    Authors: M. Sitnikova, T. Lelyavina

State Assignments

«Molecular-genetic mechanisms of heart remodeling and prognostic markers for CHF course in patients with postinfarction cardiosclerosis.»
The research review is presented in the monograph chapter “Bioenergetic homeostasis of patients with chronic heart failure. Improving mitochondrial function as a therapeutic target in CHF treatment” (supervised by M. Sitnikova, 2019—2022).

Training and education

As part of the All-Russian workshops on Cardiology and the National Healthcare Project, the specialists of the Department are implementing an extensive educational programme for doctors of the Northwestern Federal District. All practitioners have an opportunity to discuss the modern strategies and tactics for heart failure treatment, to get updated on the current rules in organizing high-tech medical care and heart transplantation, treatment methods for CHF patients and management tactics.

Maria Sitnikova is the initiator and head of the regular St. Petersburg training «Topical issues of strategy and tactics for CHF treatment», lecturer and moderator of Heart Failure training sessions held under the guidance of the Russian Society of Cardiology, Society of Heart Failure Specialists, Russian non- governmental organization for hypertension management and prevention Antihypertensive League.

Tatyana Lelyavina is the supervisor of the educational cycle «Cardiopulmonary testing in cardiology», lecturer and moderator of Heart Failure training sessions held under the guidance of the Russian Society of Cardiology, Society of Heart Failure Specialists.

Petr Fedotov is the supervisor of the educational cycle «Topical issues of heart transplantation for CHF patients», lecturer and moderator of Heart Failure training sessions held under the guidance of the Russian Society of Cardiology, Society of Heart Failure Specialists.

Major publications

Simonenko M, Fedotov P, Babenko A, Karpenko M. Frequent ventricular extrasystoles after heart transplantation: a late presentation of amiodarone-induced thyrotoxicosis: a case report. European Heart Journal – Case Reports. 2019;3 (2): ytz030/ DOI: 10.1093/ehjcr/ytz030.

Simonenko M, Fedotov P. Sex and gender issues in heart transplantation. OBM Transplantation. 2019;3 (1):1-5.DOI: 10.21926/obm.transplant.1901049.

Lelyavina, TA; Galenko, VL; Ivanova, OA; Komarova, MY; Ignatieva, EV; Bortsova, MA; Yukina, GY; Khromova, NV; Sitnikova, MY; Kostareva, AA; Sergushichev, A; Dmitrieva, RI. Clinical Response to Personalized Exercise Therapy in Heart Failure Patients with Reduced Ejection Fraction Is Accompanied by Skeletal Muscle Histological Alterations. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019; 20 (21): ID 5514 (эл.ресурс). DOI: 10.3390/ijms20215514.

Dmitrieva, RI; Lelyavina, TA; Komarova, MY; Galenko, VL; Ivanova, OA; Tikanova, PA; Khromova, NV; Golovkin, AS; Bortsova, MA; Sergushichev, A; Sitnikova, MY; Kostareva, AA. Skeletal Muscle Resident Progenitor Cells Coexpress Mesenchymal and Myogenic Markers and Are Not Affected by Chronic Heart Failure-Induced Dysregulations. STEM CELLS INTERNATIONAL. 2019; 2019: ID 5690345 (эл.ресурс). DOI: 10.1155/2019/5690345.

Vander, MA; Fedotov, PA; Lyubimtseva, TA; Bortsova, MA; Sitnikova, MY; Lebedev, DS; Mikhaylov, EN. Lenalidomide maintenance therapy in previously treated chronic lymphocytic leukaemia (CONTINUUM): a randomised, double-blind, placebo-controlled, phase 3 trial. LANCET HAEMATOLOGY. 2017; 4 (11): E53 (эл.рес.). 10.1016/S2352—3026 (17) 30168-0.

Lelyavina T, Sitnikova M, Galenko V, et al. Аerobic training in heart failure patients with optimal heart failure therapy – a prospective randomized study. World Journal of Pharmaceutical Research. 2017;6 (2):59-67.DOI:10.20959/wjpr20170-7673.

Lelyavina T.A., SitnikovaM.Yu. New physical rehabilitation program in heart failure patients. Germany:Scholars' Press, 2015. – 80 р. ISBN-13: 978-3-639-51373-8.

Patents and inventions

Patent No. 2678686, 30.01.2019, application No. 2017132601 dated 18.09.2017
«Method for pulmonary circulation preparation in recipients before heart transplantation»
Authors: M. Bortsova, A. Yakovlev, A. Bautin, V. Mazurok, P. Fedotov, S. Zayashnikov, M. Gurin, Yu. Sazonova, M. Sitnikova, M. Gordeev

Patent No. 2646749, 06.03.2018, application No. 2017121757 dated 20.06.2017
«Method for survival prediction in patients with CHF and low left ventricular ejection fraction»
Authors: L. Prokopova, M. Sitnikova, B. Smirnov

Patent No. 2646750, 06.03.2018, application No. 2017121759 dated 20.06.2017
«Method for 1-year survival prediction in patients with CHF and low left ventricular ejection fraction»
Authors: L. Prokopova, M. Sitnikova

Patent No. 2574901, 15.01.2016, application No. 2014139641 dated 30.09.2014
«Method for assessing the biological adaptation of the body to physical activity»
Authors: T. Lelyavina, M. Sitnikova.