The main aim of laboratory work is studying the molecular factors associated with smooth muscle cells in the formation and destabilization of atherosclerotic plaques and in the process of restenosis after operations.
Laboratory is active in the field of vascular biology, studying the behavior patterns of endothelial and vascular smooth muscle cells, the mechanisms of their regulation and activation. Another important focus of the laboratory work is studying the regulatory properties of microRNA in relation to smooth muscle cells, and the development of diagnostic approaches based on identification of cardiac types of microRNA.
- Molecular mechanisms of restenosis and destabilization of atherosclerotic plaques
- MicroRNA as biomarkers and regulators state of myocardial cells
Key publications of the Division
- Fedorov A., Kostareva A., Raud J., Roy J., Hedin U., Razuvaev A. Early changes of gene expression profiles in the rat model of arterial injury. Journal of Vascular and Interventional Radiology, 2014, 25:789-796.
- Kondratov K.A., Chernorudskiy A.L., Amosova A.P., Kornilova E.S. Termination of tyrphostin AG1478 application results in different recovery of EGF receptor tyrosine residues 1045 and 1173 phosphorylation in A431 cells. Cell Biol Int, 2009, 34:81-87.
- Fedorov A.V. Regulation of mammalian LINE1 retrotransposon transcription. Cell and Tissue Biol, 2009, 3:1-13.
- Galaktionov N.K., Podgornaya O.I., Fedorov A.V. Characterization of transposon mariner from the Himasthla elongata genome. Tsitologiia, 2009, 51:924-928.