Institute of Molecular Biology and Genetics


Anna Kostareva
Head of the Institute, MD, PhD

The main research areas:

The Institute of Molecular Biology and Genetics comprises:

Methods and Facilities


Selected publications

1. Kostareva A., Sjöberg G., Bruton J., Zhang S. J., Balogh J., Gudkova A., Hedberg B., Edström L., Westerblad H., Sejersen T.

Mice expressing L345P mutant desmin exhibit morphological and functional changes of skeletal and cardiac mitochondria.

J Muscle Res Cell Motil. 2008; 29 (1): 25-36. Epub 2008 Jun 19.

2. Kostareva A., Gudkova A., Sjöberg G., Mörner S., Semernin E., Krutikov A., Shlyakhto E., Sejersen T.

Deletion in TNNI3 gene is associated with restrictive cardiomyopathy.

Int J Cardiol. 2007 Nov 12. [Epub ahead of print]

3. Anna Kostareva, Alexandra Gudkova, Gunnar Sjoberg, Ivan Kiselev, Olga Moiseeva, Elena Karelkina, Lev Goldfarb, Eugeniy Schlyakhto and Thomas Sejersen.

Desmin mutations in a St.Petersburg cohort of cardiomyopathies. Acta Myologica, 2006, 2006 Dec; 25 (3): 109-15.

4. Goudeau B., Rodrigues-Lima F., Fischer D., Casteras-Simon M., Sambuughin N., de Visser M., Laforet P., Ferrer X., Chapon F., Sjoberg G., Kostareva A., Sejersen T., Dalakas M. C., Goldfarb L. G., Vicart P.

Variable pathogenic potentials of mutations located in the desmin alpha-helical domain. Hum Mutat. 2006 Sep; 27 (9): 906-13.

5. Bar H., Kostareva A., Sjoberg G., Sejersen T., Katus H. A., Herrmann H.

Forced expression of desmin and desmin mutants in cultured cells: impact of myopathic missense mutations in the central coiled-coil domain on network formation. Exp Cell Res. 2006 May 15; 312 (9): 1554-65. Epub 2006 Mar 7.

6. Bar H., Mucke N., Kostareva A., Sjoberg G., Aebi U., Herrmann H.

Severe muscle disease-causing desmin mutations interfere with in vitro filament assembly at distinct stages. Proc Natl Acad Sci U S A. 2005 Oct 18; 102 (42): 15099-104. Epub 2005 Oct 10.

7. Sjöberg G., Kostareva A., Sejersen T.

[Hereditary cardiomyopathies: a review. Mutation of structural proteins a common cause of hereditary cardiomyopathy]. Lakartidningen. 2005 Mar 14-20; 102 (11): 845-7, 850-3. Review. Swedish.

8. Grineva E., Babenko A., Vahrameeva N., Bogdanova M., Kostareva A., Popcova D., Larionova V.

Type 2 deiodinase Thr92Ala polymorphism impact on clinical course and myocardial remodeling in patients with Graves' disease. Cell Cycle. 2009: 15; 8 (16): 2565-9.

9. Malashicheva A., Kanzler B., Tolkunova E., Trono D., Tomilin A.

Lentivirus as a tool for lineage-specific gene manipulations. Genesis. 2007 Jul; 45 (7): 456-459.

10. Tolkunova E., Malashicheva A., Parfenov V. N., Sustmann C., Grosschedl R., Tomilin A.

PIAS proteins as repressors of Oct4 function. J Mol Biol. 2007 Dec 14; 374 (5): 1200—1212.

11. Aksoy I., Sakabedoyan C., Bourillot P. Y., Malashicheva A. B., Mancip J., Knoblauch K., Afanassieff M., Savatier P.

Self-renewal of murine embryonic stem cells is supported by the serine/threonine kinases pim-1 and pim-3. Stem Cells. 2007 Dec; 25 (12): 2996—3004.

12. Enukashvily N. I., Malashicheva A. B., Waisertreiger I. S.

Satellite DNA spatial localization and transcriptional activity in mouse embryonic E-14 and IOUD2 stem cells. Cytogenet Genome Res. 2009; 124 (3-4): 277-87. Epub 2009 Jun 25

13. Correia A. S., Anisimov S. V., Li J. Y., Brundin P.

Growth factors and feeder cells promote differentiation of human embryonic stem cells into dopaminergic neurons: a novel role for fibroblast growth factor-20. Front Neurosci. 2008 Jul; 2 (1): 26-34. Epub 2008 Jul 7. PMID: 18982104 [PubMed — in process] Related articlesFree article

14. Anisimov S. V., Tarasov K. V., Riordon D., Wobus A. M., Boheler K.R.

SAGE Identification of Differentiation Responsive Genes in P19 Embryonic Cells Induced to Form Cardiomyocytes in vitro. (2002) Mechanisms of Development 117: (1-2): 25-74.

15. Anisimov S. V., Sharov A. A.

Incidence of «quasi-ditags» in catalogs generated by Serial Analysis of Gene Expression (SAGE). (2004) BMC Bioinformatics 5: (1): 152.

16. Anisimov S. V., Christophersen N. S., Correia S. A., Li J. Y., Brundin P.

“NeuroStem Chip”: a novel highly specialized tool to study neural differentiation pathways in human stem cell. (2007) BMC Genomics 8: (1): 46.

17. Anisimov S. V.

Cell-based Therapeutic Approaches for Parkinson’s Disease: Progress and Perspectives. Reviews in the Neurosciences (2009) 20: (5-6): 347-381.

18. Anisimov S. V., Morizane A., Correia S. A.

Risks and mechanisms of oncological disease following stem cell transplantation. Stem Cell Reviews and Reports (2010) 6: (3): 411-424.

19. Coia V., Jüliger S., Mordmüller B., Kreidenweis A., Stroh A. L., Ortega C., Vindigni A., Dengjel J., Lukyanov D. V., Destro-Bisol G., Fedorov A., Podgornaya O. I., Kun J. F.

Analysis of polymorphic sites in the promoter of the nitric oxide synthase 2 gene.

Biochem Biophys Res Commun. 2005 Oct 7; 335 (4): 1123-31.

20. Fedorov A., Lukyanov D., Rogoliński J., Widłak P., Podgornaya O., Rzeszowska-Wolny J.

The nuclear protein p30 specifically interacts with a nuclear matrix attachment region from the rat genome. Cell Mol Biol Lett. 2004; 9 (1): 153-65.

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