Research Department of Microcirculation and Myocardial Metabolism

 
Dmitry Sonin, MD, PhD
Head of Department

The Research Department of Microcirculation and Myocardial Metabolism was established in 2016 as part of the Centre for Experimental Biomodeling.

Major research areas

Research is carried out in close collaboration with other laboratories of the Institute of Experimental Medicine as well as scientific and clinical units of Almazov Centre.

Major areas include:

  • Myocardial protection against ischemia/reperfusion injury by pre- and postconditioning in the experiment and clinical practice
  • Development of methods for targeted drug delivery to the ischemic myocardium using nanocarriers
  • Pharmacological and non-pharmacological cerebral protection against ischemia/reperfusion injury
  • Study of mechanisms and methods for assessing brain damage in rat stroke models
  • Stimulation of myocardial regeneration after injury by activating the differentiation of resident progenitor cells and mesenchymal stem cells
  • Optimization of surgical approaches to repair metabolic disorders in type 2 diabetes mellitus in the experimental model of diabetes mellitus and in patients with type 2 diabetes mellitus and BMI of 30–35 kg/m2
  • Studying the pathophysiology of microcirculation and hemostasis
  • Development of fluorescence imaging methods for ischemia and other forms of tissue damage

Key achievements and results

Ongoing research and development prospects

Participation in scientific programs

Collaboration

The Research Department of Microcirculation and Myocardial Metabolism has many years of cooperation with leading universities and research institutions of St. Petersburg and Moscow, including St. Petersburg State University, Peter the Great St. Petersburg Polytechnic University, Pavlov First State Medical University, ITMO University, National Medical Research Radiology Center, Moscow State University of Fine Chemical Technologies, Moscow Technological University, Sechenov Institute of Evolutionary Physiology and Biochemistry, etc.

International collaboration includes projects with the University of Oslo (Norway) and the University of Iowa (USA).

Major publications

D. Sonin, G. Papayan, E. Pochkaeva, S. Chefu, S. Minasian, D. Kurapeev, J. Vaage, N. Petrishchev, and М.lGalagudza.In vivo visualization and ex vivo quantification of experimental myocardial infarction by indocyanine green fluorescence imaging.Biomedical Optics Expres. Vol. 8, Issue 1,p. 151-161. 2017

Galagudza M., Sonin D., Vlasov T., Kurapeev D., Shlyakhto E. Remote versus local ischemic preconditioning in the rat heart: infarctlimitation, suppression of ischemic arrhythmia, and the role of reactive oxygen species // European Heart Journal Supplements. – 2016. – V.97. –№ 1. – Р 66-74.

Sonin D. L., Korolev D. V., Postnov V. N., Naumysheva E. B., Pochkaeva E. I., Vasyutina M. L., Galagudza M. M. Silicon-containing nanocarriers for targeted drug delivery: synthesis, physicochemical properties and acute toxicity // Drug Delivery. – 2015. – Published online: 23 Jul 2015. – P. 1-10. – doi: 10.3109/10717544.2015.1069421.

KangUk, PapayanG,V., ObuckhovaN.F., BaeS.J., LeeD.S., JungM.W., BerezinV/B. MotikoF.F., PlochichD.G., SljbodeniukC.f. Complex for fluorescent diagnostics and photodynamic therapy of cervical disease. J. Opt. Technol. N12. 47-59. 2015.

A.Kondratyev, A.Lyaptsev, I.Mikhailova.Mathematical Modeling of Thrombus Growth. Phenomenological Models. Applied Mathematical Sciences.V.9 .N 9.p.429-446 . 2015.

Petrishchev N.N. Papayan G.V. GryshachovaT.G ., Mikhailova I.A…Struy A.V. Photoreactivity of microvessels of rat mesenteric vascular bed/ J.Vasc.Res, V.52 (Suppl 1). p.14. 2015.