Head of Research Group
The Experimental Pathology Group was established in November 2013. It carries out scientific work in collaboration with other laboratories of the Institute of Experimental Medicine.
- Developing the experimental models of diseases appropriate for translational medicine tasks
- Morphological screening of acute and chronic toxicity of inorganic and organic materials, proposed as matrices for dispersed drug delivery systems
- Developing the methods for monitoring and visualizing permeability, biodistribution in target organs and bioelimination of exogenous dispersed particles of nano and submicron sizes proposed as a means of drug delivery
- Morphological analysis of the biodistribution of nanoparticles based on the natural polymer – chitosan
- Currently, the studies are underway to assess the effect of various nanoscale carriers on the histological picture of internal organs (liver, spleen, lungs, kidney, brain). It was found that a single intravenous infusion of silicon and silica nanoparticles leads to the formation of foreign-body granulomas in the organs of the reticuloendothelial system. Morphometric analysis showed that the total area of granulomas did not decrease from 5 to 60 days after the infusion of nanoparticles. These findings suggest that inorganic nanoscale carriers do not have an optimal biodegradation profile to be used as drug carriers. At present, a pathomorphological study is planned to assess the chronic toxicity of organically modified silica nanoparticles.
- Drafted the concept of targeted delivery taking into account the phenomenon of nonspecifically elevated cyto-availability.
- Identified the property of the natural biopolymer, chitosan, structurally organized as dispersed particles of nano- and submicron sizes to penetrate the hematolabyrinth barrier by non-specific mechanisms.
Prospects for 2017–2018
- Adopting the method of immunohistochemical analysis of histological material
- Participation in preclinical studies of new pharmaceutical ingredients and medical devices
- Validating and developing the technology of targeted drug delivery to the lymphoid tissues of organs in contact with the external environment
- Searching for methods of artificial structural modification of the vestibular receptor site
- Laboratories of Pathology, Hearing and Speech, Research Centre of Pavlov First St. Petersburg State Medical University
- Laboratory of Natural Polymers, Institute of Macromolecular Compounds, Russian Academy of Sciences
- Department of Micro- and Nanoelectronics, LETI Electrotechnical University
- Laboratory of evolution of sense organs, Sechenov Institute of Evolutionary Physiology and Biochemistry
Mast cell accumulation precedes tissue fibrosis induced by intravenously administered amorphous silica nanoparticles / S. Zhuravskii, G. Yukina, O. Kulikova [et al.] // Toxicol. Mech. Methods. – 2016.– Vol. 26. – № 4. – Р.260-269.
In vivo toxicity of intravenously administered silica and silicon nanoparticles / S. Ivanov, S. Zhuravsky, G. Yukina [et al.] // Materials. – 2012. – V. 5. – № 10. – P. 1873–1889 (IF JCR 2011 = 1.661).