Head of the Experimental Pathomorphology Research Group, MD
Experimental Pathomorphology Research Group of the Institute of Experimental Medicine was organized by the Academic Council of Federal Almazov North-West Medical Research Centre in November 2013.
The scientific work is performed in collaboration with other laboratories of the Institute of Experimental Medicine.
Scientific activity of the group:
- Development of experimental models of pathologies appropriate in translational medicine context.
- Morpho-functional screening of acute and chronic organotoxicity and inorganic and organic materials proposed as substrates for the synthesis of parenteral carriers for targeted drug delivery.
- Development of methods for monitoring and visualization of permeability, accumulation in target organs and excretion of exogenous dispersed nanoparticles of various materials proposed as a transport for targeted drug delivery.
- Preclinical studies on the development of a universal drug delivery transporter|vehicle on the basis of natural biopolymer — chitosan.
- The fundamental aspects study of the organization of the barrier and digestive function of the intestinal mucosa of mammals in terms of cause-effect relationships of metabolic, endocrine, and cardiovascular diseases.
- Study of S. P. Botkin's scientific heritage: developing scientific comments and preparation of archival epistolary and documents diary for publication.
Group main achievements:
- Currently we conduct the studies to assess the impact of various nanoscale carriers on internal organs histology (liver, spleen, kidney, brain). We found that a single intravenous infusion of silicon and silica nanoparticles leads to the formation of granulomas in reticuloendothelial system organs. Morphometric analysis showed that the granulomas total area wasn’t reduced from 5th to 60th day after infusion of the nanoparticles. These data allow us to suggest that the nanoscale inorganic carriers do not have an optimum biodegradation profile for drug carriers’ use. Currently we plan the mortem examination to assess the chronic toxicity of nanoparticles organo-silica.
- We hypothesized the way of targeted drug delivery to the tissues on the basis of non-specifically increased permeability of the barriers by intensifying general biological phenomena of macrophage activity and endocytosis.
- We found the property of natural biopolymer chitosan structurally organized in the form of dispersed nanoparticles and submicron size to increase the permeability of the blood-labyrinth barrier for the drugs.
In the long-term plan for 2014–2015 we plan work linked with the establishment of pathological and immunohistochemical methods of research in the Laboratory of Experimental Pathomorphology in the new building of the Institute of Experimental Medicine at 15 Parkhomenko Street.
- Department of Pathological Anatomy and Research Centre Laboratories of Pavlov State Medical University
- Institute of Macromolecular Compounds of Russian Academy of Sciences