Sleep Medicine Laboratory

 

Sleep Medicine Laboratory was opened in 2013 as an independent structural Division and part of the Research Department for Hypertension of the Institute of Heart and Vessels of Federal Almazov North-West Medical Research Centre. However, medical staff of the Research Department for Hypertension has been consulting patients for sleep disorders since 2002. Doctor Yurri Sviryaev is the Head of the laboratory (Hirsh index Russian Citation index – 4.0, Hirsh index Scopus – 2.0).

The staff of the Sleep Medicine Laboratory had passed the training in the leading worldwide laboratories (Center for Circadian and Sleep Medicine, Northwestern University Feinberg School of Medicine, Chicago, Il, USA; Neurocentro della Svizzera Italiana, Lugano, Switzerland; Sleep-Wake-Epilepsy Centre, Bern University Hospital, Switzerland; ESRS Marie Curie project “Training in Sleep Research”), and are certified by ESRS (certificates “Somnologist – Expert in Sleep Medicine”).

Activities

Clinical, research and education activities are implemented by the lab staff.

Clinical work

Clinical work includes both out-patient and in-patient consulting in the Federal Almazov North-West Medical Research Centre.

All 4 types of diagnostic devices (according to the AASM classification) are available in the lab, including attended in-lab full video-polysomnography; unattended polysomnography; cardiorespiratory monitoring (with a simultaneous 12-channel ECG monitoring) and night pulseoximetry with a simultaneous oronasal airflow registration. The last 2 types are considered to be screening tools, and are used for the primary diagnostics only. For the diagnostics of circadian rhythm disorders actigraphy is also available.

In addition, different types of therapeutic devices for CPAP/BiPAP-therapy are available in the laboratory, and titration sleep studies are performed for better choice of treatment regimen and pressure level. Patients who get CPAP/BiPAP therapy are followed-up, and the impact of pathogenetic treatment on clinical and laboratory parameters, prognosis, and the benefits of therapy in the management of heart rhythm and conductive disturbances are assessed. A complex application of non-invasive ventilation is performed in the laboratory, and if necessary oxygen-concentrator is used along with CPAP/BiPAP-therapy.

Besides sleep breathing disorders, the diagnostics and management of circadian rhythm disorders are also implemented. We are involved in the complex diagnosis of patients with insomnia and other sleep disorders. We collaborate with experts in various fields (neurology, endocrinology and Ear Nose Throat doctors) working in the Federal Almazov North-West Medical Research Centre and other leading institutions in St. Petersburg. It allows us to provide an integrated approach to the diagnosis and treatment of various sleep disorders.

Diagnosis and correction of sleep disorders in children is provided by the medical staff of the Perinatal Center of Federal Almazov North-West Medical Research Centre.

Research

Clinical research focuses on sleep disorders and their association with cardiovascular diseases, their prognostic role and prevention approaches. As a result, 3 candidate and one doctoral theses were defended.
The ongoing research includes the studies of effects of PAP-therapy on heart rhythm and conduction disorders. Within the International Project “Seventh Framework Programme” patients with congestive heart failure are also examined and followed-up in sleep laboratory. A project directed at sleep disorders assessment in patients referred for heart transplantation has been initiated. We provide a survey of the St. Petersburg population with the Research Laboratory for Epidemiology of Hypertension as a part of the large-scale epidemiological studies to assess cardiovascular disease in different regions of the Russian Federation.
Together with pediatricians from the Perinatal Centre we assess the role of sleep disorders for neurocognitive development, emotional and behavioral characteristics and metabolic parameters in children.

Grant-supported projects

Russian Fundamental Research Foundation, #15-07-02472 А: The development of the algorithm for the non-contact evaluation of sleep in humans, based on bioradiolocation monitoring, 2015—2017.

Project «The development of a portable device for multifunctional cardiovascular monitoring and sleep-wake cycle assessment», State Grant for Young Russian Scientists, 2015

Russian Humanitarian Scientific Foundation #14-06-00219: Theoretical and experimental study of the screening surveys of sleep quality for prevention and preclinical management of socially important diseases, 2014—2016.
Grant of St Petersburg Administration for students, postgraduate students, young scientists and young PhDs for 2013, diploma PSP #13218, project «Prognostic role of obstructive sleep apnea syndrome for the development of glucose metabolism disorders»

Russian Fundamental Research Foundation, #14-07-31151, young investigators: Development of the Algorithms for Sleep Architecture Detection Based on the Cardiorespiratory Variability, 2014—2015.

Russian Fundamental Research Foundation, #14-07-00019A: Theoretical and Experimental Study for the Development of Algorithm for Spectral Heart Rhythm Variability Analysis in Human Short ECG Recordings, 2014

Russian Humanitarian Scientific Foundation, #14-06-00219: Theoretical and Experimental Basis for the Development of the Screening Surveys of Sleep Quality for the Prevention and Pre-clinical Management of Stress-induced Social Diseases, 2014—2016

Russian Fundamental Research Foundation, #12-07-31014: Research and Development of Methods and Algorithms for Nonstationary Bio-radiolocation Signals Pattern Recognition for Non-contact Screening Diagnostics of Sleep-disordered Breathing. Russian Foundation of Fundamental Research (2012)

Awards

2013 – Diploma PSP №13218, grant for the students, PhD students and young investigators and PhDs of St Petersburg 2013.
2014 – WASM award for the best World Sleep Day 2014.

Education

The staff of Sleep Medicine Laboratory gives lectures at the Advanced Training courses for cardiologists, specialists in functional diagnostics regarding management of sleep disorders (teaching courses “Innovation technologies in treatment of hypertension” etc.), take part in the project of continuous medical education, have created a course for on-line education (http://www.sovetnmo.ru/modules/221.html?SSr=0801337ad901ffffffff27c__07df0a01010805-1514).

Collaboration

Sleep Medicine Laboratory collaborates within colleagues from Almazov North-West Federal Medical Research Centre (neurologists, endocrinologists, ENT-doctors, psychologists and psychotherapists), as well as with different national and foreign institutions. The national collaborators include Institution of the evolutionary physiology and biochemistry n.a. I.M. Sechenov, First Pavlov State Medical University of St. Petersburg, Herzen State Pedagogical University of Russia, Clinical Multidisciplinary Clinic № 2, St Petersburg Clinical Hospital of Russian Academy of Sciences, Sleep Medicine Centre at the Federal Research Clinical Centre FMBA in Moscow etc. Together with INKART company the sleep diagnostic algorithms are being developed for the further implementation in the portable electrocardiogram and blood pressure monitoring systems.
The international collaborators include Bern University Hospital (Professor CL Bassetti, Head, Department of Neurology, Switzerland), Medical University of Gdansk (Professor K. Narkiewicz, Head, Department of Hypertension and Diabetology, Poland), S. Luca Hospital, IRCS Istituto Auxologico Italiano (Professor G. Parati, Department of Cardiology, Milan).

Social activities

The personnel of the Sleep Medicine Laboratory actively participates in different social events, propagates healthy sleep and popularizes prevention and treatment of sleep disorders: presents lectures for people with cardiovascular and other diseases, gives interviews on TV, radio and other media.
In 2014 and 2015, together with somnologists from Moscow different activities for the World Sleep Day were organized. The activity was awarded by the World Association of Sleep Medicine: “Distinguished Activity Award” 2014 and 2015.

Selected publication (for the last 5 years)

1. Korostovtseva L, Sazonova Yu, Semenov A, Nepran V, Zvartau N, Bochkarev M, Nikolaev G, Sviryaev Yu, Gordeev M, Konradi A. Mixed Apnea Associated with Non-Rapid Eye Movement Sleep a Reversible Compensatory Sign of Heart Failure? Am J Case Rep. Am J Case Rep, 2015; 16: DOI: 10.12659/AJCR.894974 [Accepted].
2. Tsoi UA, Sviryaev IuV, Korostovtseva LS, Semenov AP, Vaulina DA, Nepran VI, Kravchenko SO, Konradi AO, Grineva EN. [Clinical features of obstructive sleep apnea syndrome in patients with acromegaly]. Ter Arkh. 2015;87 (4):47-52. Russian. PubMed PMID: 26087634.
3. Dmitrieva RI, Revittser AV, Klukina MA, Sviryaev YV, Korostovtseva LS, Kostareva AA, Zaritskey AY, Shlyakhto EV. Functional properties of bone marrow derived multipotent mesenchymal stromal cells are altered in heart failure patients, and could be corrected by adjustment of expansion strategies. Aging (Albany NY). 2015 Jan;7 (1):14-25. PubMed PMID: 25606985; PubMed Central PMCID: PMC4350322.
4. Korostovtseva LS, Zvartau NE, Barantsevich ER, Konradi AO. [The choice of the antihypertensive drug in special conditions: evidence-based data in co-morbid neurology diseases (part 5)]. Arterial’naya Gipertenziya = Arterial Hypertension. 2015;21 (1):116-120 [Russian].
5. Lisovskaya N.A., Korostovtseva L.S., Dubinina E.A., Obraztsova G.I., Sviryaev Y.V. [The relation between obstructive sleep apnea syndrome and cognitive dysfunction in children]. Arterial’naya Gipertenziya = Arterial Hypertension. 2015;21 (1):101-110 [Russian].
6. Korostovtseva L, Sviryaev Y, Zvartau N, Druzhkova T, Tikhonenko V, Konradi A. New insights into the management of rhythm and conduction disorders after acute myocardial infarction. Am J Case Rep. 2014 Apr 19;15:159-62. doi: 10.12659/AJCR.890357. eCollection 2014. PubMed PMID: 24782917; PubMed Central PMCID: PMC4003152.
7. Minullina IR, Alexeyeva NP, Anisimov SV, Puzanov MV, Kozlova SN, Sviryaev YV, Zaritskey AY, Shlyakhto EV. Transcriptional changes in bone marrow stromal cells of patients with heart failure. Cell Cycle. 2014;13 (9):1495-500. doi: 10.4161/cc.28472.
8. Tataraidze A, Anishchenko L, Alekhin M, Korostovtseva L, Sviryaev Y. Estimation of respiratory rhythm during night sleep using a bio-radar. Proceedings of SPIE — The International Society for Optical Engineering. 2014. Vol. 9077. 90770Z-6.
9. Bochkarev MV, Korostovtseva LS, Sviryaev YuV. Sleep quality and duration and cardiovascular diseases: is there an association? Arterial’naya Gipertenziya = Arterial Hypertension. 2014;20 (5):450-461. [Russian].
10. Kot TL, Bochkarev MV, Nikiforova EI. [Photoperiodic seasonal exacerbations and social status in patients with exogenous and endogenous depression living in Northern region of Russia]. Bulleten of Kyrgyzstan-Russian Slavic University. 2014;14 (4):110-112 [Russian].
11. Korostovtseva LS, Zvartau NE, Sviryaev YV, Konradi AO. [The choice of the antihypertensive drug in special conditions: evidence-based data in co-morbid hypertension and metabolic disorders (part 3)]. Arterial’naya Gipertenziya = Arterial Hypertension. 2014;20 (5):370-376 [Russian].
12. Dubinina EA, Korostovtseva LS, Rotar OP, Moguchaia EV, Boyarinova MA, Kolesova EP, Alieva AS, Dudorova EA, Kravchenko SO, Paskar NA, Sviryaev YV, Alekhin AN, Konradi AO. [The association between self-reported sleep disorders and emotional complaints: the results of the screening study in adult St Petersburg citizens.] Arterial’naya Gipertenziya = Arterial Hypertension. 2014;20 (4):269-279 [Russian].
13. Dubinina EA, Korostovtseva LS, Rotar OP, Moguchaia EV, Boyarinova MA, Kolesova EP, Alieva AS, Kravchenko SO, Paskar NA, Sviryaev YV, Alekhin AN, Konradi AO. [Association between sleep disordered breathing, emotional complaints and anthropometric parameters (based on screening survey of St Petersburg citizens).] Russian Cardiology Journal. 2014;11 (115):31-37. [Russian].
14. Tsoi UA, Korostovtseva LS, Sviryaev IuV, Semenov AP, Vaulina DA, Kravchenko SO, Konradi AO, Grineva EN. [Prevalence of sleep disordered breathing in newly diagnosed acromegaly. Almanac of Clinical Medicine]. 2014;32:36-42. [Russian].
15. Alekhin M, Anishchenko L, Tataraidze A, Ivashov S, Parashin V, Korostovtseva L, Sviryaev Y, Bogomolov A. A Novel Method for Recognition of Bioradiolocation Signal Breathing Patterns for Noncontact Screening of Sleep Apnea Syndrome. International Journal of Antennas and Propagation. Volume 2013 (2013), Article ID: 969603, 8 pages.
16. Alekhin MD, Anishchenko LN, Tataraidze AB, Ivashov SI, Korostovtseva LS, Sviryaev YV, Bogomolov AV. Selection of wavelet transform and neural network parameters for classification of breathing patterns of bio-radiolocation signals. communications in computer and information science. Proceedings of the First International Aizu Conference on Biomedical Informatics and Technology (ACBIT 2013). Springer, Heidelberg. 2013. Vol. 404. P. 327-330.
17. Alekhin MD, Anishchenko LN, Zhuravlev AV, Ivashov SI, Korostovtseva LS, Sviriaev IuV, Konradi AO, Parashin VB, Bogomolov AV. [Estimation of the information value of diagnostic data obtained by bio-radiolocation pneumography in non-contact screening of sleep apnea syndrome]. Med Tekh. 2013 Mar-Apr;(2):36-8. Russian. PubMed PMID: 23789156.
18. Rotar OP, Trifonova EA, Korostovtseva LS, Erina AA, Boiarinova MA, Kolesova EP, Dudorova EA, Alekhin AN, Konradi АО, Tanicheva AA. Health behaviours and attitudes in young and middle-aged Saint-Petersburg citizens (Russia). J Addiction Res. Ther. 2012. S8.
19. Konradi AO, Rotar OP, Korostovtseva LS, Ivanenko VV, Solntcev VN, Anokhin SB, Bart VA, Shlyakhto EV. Prevalence of metabolic syndrome components in a population of bank employees from St. Petersburg, Russia. Metab Syndr Relat Disord. 2011 Oct;9 (5):337-43. doi: 10.1089/met.2011.0028. PubMed PMID: 21819220.
20. Korostovtseva LS, Sviryaev YV, Zvartau NE, Konradi AO, Kalinkin AL. Prognosis and cardiovascular morbidity and mortality in prospective study of hypertensive patients with obstructive sleep apnea syndrome in St Petersburg, Russia. Med Sci Monit. 2011 Feb 25;17 (3):CR146-53. PubMed PMID: 21358601; PubMed Central PMCID:PMC3524738.

Theses completed in the lab
Korostovtseva LS. Prognostic role of obstructive sleep apnea syndrome in hypertensive obese patients. PhD thesis (Candidate of Science): 14.01.05, St Petersburg, 2013.
Svuryaev YuV. Obstructive sleep apnea syndrome in patients with hypertension and obesity. PhD thesis (Doctor of Science). St Petersburg, 2010.
Rotar OP. Heart remodeling and endothelial function in patients with obesity, hypertension and obstructive sleep apnea syndrome, PhD thesis (Candidate of Science), St Petersburg, 2007.
Zvartau NE. Metabolic and neurohumoral changes in patients with obesity, hypertension and obstructive sleep apnea syndrome, PhD thesis (Candidate of Science), St Petersburg, 2005.