Laboratory of Cerebrovascular Disease

 
Prof. Vladimir Semenyutin, DSc in Biology
Head of Laboratory

The Research Laboratory of Cerebrovascular Disease was established in 1971 by Director of the Leningrad Research Institute of Neurosurgery named after A.L. Polenov, Honored Scientist, Professor Veniamin Ugryumov.

Major research areas

  • Studying the mechanisms of cerebral circulation and developing methods for early diagnosis and prediction of cerebrovascular dysregulation in patients with various neurosurgical conditions.
  • Developing a system for assessing and predicting cerebral blood flow disorders and determining the indications and timing for surgical treatment in the acute and late periods following aneurysm rupture and brain injury using the frequency analysis of slow-wave oscillations in systemic and cerebral hemodynamics
  • Studying the pathogenesis of circulatory disorders in the perinidal area of arteriovenous malformations and the mechanism of blood flow redistribution in the territories of afferent vessels at different stages of embolization using new methods for measuring the degree of their exclusion through the combined use of duplex scanning of the precerebral arteries and monitoring of linear velocity in the basilar vessels.
  • Identifying the informative predictors of stroke in patients with carotid artery stenosis and occlusion to clarify the indications for surgical repair during perioperative monitoring of cerebral blood flow autoregulation rate and flow velocity index in precerebral arteries.
  • Developing a software and hardware system for non-invasive real-time diagnostics of the state of cerebral blood flow autoregulation.
Scientific events

The specialists of the Laboratory are actively involved in various scientific events in Russia and worldwide. In the past 10 years, they have given 22 presentations at Russian and 35 presentations at international scientific events:

Joint Meeting of the French and Russian Societies of Neurosurgery, Caen, France, March 29-April 1, 2006

11th Meeting of the European Society of Neurosonology and Cerebral Hemodynamics, Dusseldorf, Germany, May 13-16, 2006

International conference Statistical Methods for Biomedical and Technical Systems, Limassol, Cyprus, 2006

IV Russian Congress of Neurosurgery, Moscow, June, 18-22, 2006

10th congress of Baltic neurosurgical association and conference of neuronursers Palanga, Lithuania, September 14-16, 2006

12th Meeting of the European Society of Neurosonology and Cerebral Hemodynamics, Budapest, Hungary, May 26-29, 2007

13th Meeting of the European Society of Neurosonology and Cerebral Hemodynamics. Genova, Italy, May 10-13, 2008

Endovascular surgery Bringing Basic Science into Clinical Practice, Stockholm, Sweden, 19-21 March 2009

14th Meeting of the European Society of Neurosonology and Cerebral Hemodynamics, Riga, Latvia, May 23-25, 2009

V Russian Congress of Neurosurgery, Ufa, 2009

1 Kazakhstan Congress of Neurosurgery with international participation, Astana, July 22-24, 2009

6th Black Sea Neurosurgical Congress, Istanbul, Turkey, October 16 – 18, 2009

Scientific and Practical Conference of Nizhny Novgorod Neurosurgical Center, Vologda, May 12-13, 2010

15th Meeting of the European Society of Neurosonology and Cerebral Hemodynamics, Madrid, Spain, May 22-25, 2010

16th Meeting of the European Society of Neurosonology and Cerebral Hemodynamics, Munich, Germany, May 20-23, 2011

International Translational Neuroscience Conference, Kaunas, Lithuania, 16-17 June, 2011

17th Meeting of the European Society of Neurosonology and Cerebral Hemodynamics, Venice, Italy, May 17-20, 2012

International Siberian Neurosurgical Forum, Novosibirsk, 2012

18th Meeting of the European Society of Neurosonology and Cerebral Hemodynamics, Porto, Portugal, May 24-27, 2013.

19th Meeting of the European Society of Neurosonology and Cerebral Hemodynamics, Rome, Italy, May 10-13, 2014.

2nd World AVM congress, Nancy, France, 18-20 June, 2014

Clinical Neurophysiology and Neurorehabilitation, scientific and practical conference with international participation, Saint Petersburg, November 25-26, 2014

International Scientific Forum “Multipurpose Clinic of the XXI Century”, Saint Petersburg, April 09-11, 2015

20th Meeting of the European Society of Neurosonology and Cerebral Hemodynamics, Zadar, Croatia, May 7-11, 2015

21th Meeting of the ESNCH, Budapest, Hungary, Europe 13-16 May, 2016

1st Meeting of the National Society of Neurosonology and Cerebral Hemodynamics, Saint Petersburg, June 9, 2016

2nd Meeting of the National Society of Neurosonology and Cerebral Hemodynamics, Saint Petersburg, December 16, 2016

Polenov’s Readings, IX All-Russian Scientific and practical Conference, Saint Petersburg, April 19-21, 2017

22th Meeting of the ESNCH, Berlin, Germany, Europe 19-21 May, 2017

3rd Meeting of the National Society of Neurosonology and Cerebral Hemodynamics, Saint Petersburg, June 1, 2017

23rd Meeting of the ESNCH, Prague, Czech Republic, Europe, 13–16 April, 2018

24th Meeting of the ESNCH, Linz, Austria, Europe, 5–7 April, 2019

International Symposium on Intracranial Pressure and Neuromonitoring, Leuven, Belgium, Europe 08–11 Sep 2019

9th International Meeting on Cerebral Haemodynamic Regulation (CARNet meeting), Leuven, Belgium, Europe 12–13 Sep 2019

Collaboration
  • MoU on scientific and technical cooperation with the Institute of Vegetative Physiology of the Johannes Müller Center for Physiology, University Hospital Charité, Humboldt-University, Berlin, Germany: Studying the mechanisms of cerebral circulation and developing methods for early diagnosis and prediction of cerebrovascular dysregulation in patients with various neurosurgical conditions. It is planned to develop a software and hardware system for real-time assessment of autoregulation and assessment of the effect of contrast agents on cerebral blood flow and its autoregulation in an in vitro model of cerebral vasospasm.
  • Agreement on scientific and technical cooperation with the Saint Petersburg State Polytechnic University: Establishing core facility centres for the development of computer technologies for the analysis of regulation in biological systems, organizing a scientific and educational centre with the task of combining material and intellectual resources to increase the educational and scientific potential as part of the innovation process.
Selected publications

Zubkov Y., Semenyutin V., Benaschvili G., Alexander L.F., Smith R.R., Tarassoli Y. Cerebral Blood Flow Following Angioplasty for Vasospasm. Developments in Neurology 8, Edd.J.Max Findlay, Cerebral Vasospasm, Elsevier, 1993, pgs.325-327.

Zubkov Y. N., Semenyutin V. B., Tarassoli Y. Dynamic cerebral Blood Flow Changes before and after Angioplasty for Vasospasm. The Canadian Journal of Neurological Sciences. V.20.(Suppl.1), 1993, pgs.10.

Zubkov Y. N., Alexander L. F., Smith R. R., Benashvili G. M., Semenyutin V. B., Bernanke D. Angioplasty of vasospasm: Is it reasonable? — Neurological Research, 1994, Vol.16, February, pgs. 9-11.

Makevnina L. G., Lomova I. P., Zubkov Yu. N., Semenyutin V. B. Kininogens consumption in cerebral circulation of human during brain ischemia and postischemic reperfusion // Braz J of Med Biol Res, 1994, V.27, N8. P.1955-63.

Semenyutin V. B., Michel J., Orlov V., Govorov B. B. Regulatory mechanisms of cerebral blood flow under standardised psychic load. EMS Journal Neurophysilogy Neurosonology, St.Petersburg, June, 1997, p.369-373.

Semenyutin V. B., Aliev V. A., Nikitin P. I., Kozlov A. V. The intracranial B-waves’ amplitude as prognostication criterion of neurological complications in neuroendovascular interventions // Acta Neurochirurgica, 2005, Suppl. 94. P.53-58.

Semenyutin V. В., Aliev V. A., Patzak A., Kozlov A. V., Nikitin P. I. The system of cerebral circulation: an assessment of its state with cross-spectral analysis. Proceedings of the International conference Statistical Methods for Biomedical and Technical Systems, Limassol, Cyprus, Nicosia, 2006, P.441-448.

Semenyutin V. B., Pechiborsch D. A., Olyushin V. E., Aliev V. A., Chirkin V. Y., Kozlov A. V. Intraoperative color-coded duplex sonography of the superior sagittal sinus in parasagittal meningiomas. New Trends in Neurosonology and Cerebral Hemodynamics. Perspectives in Medicine. Volume 1. 2012. P.395-398.

Semenyutin V. B., Aliev V. A., Bersnev V. P., Patzak A., Rozhchenko L. V., Kozlov A. V., Ramazanov Sh. Sh. Informativity of pulsatility index and cerebral autoregulation in hydrocephalus. New Trends in Neurosonology and Cerebral Hemodynamics. Perspectives in Medicine. Volume 1. 2012. P.311-315.

Semenyutin V. B., Panuntsev G. K., Aliev V. A., Patzak A., Pechiborsch D. A, Kozlov A. V. Capability of assessment of cerebral autoregulation in perinidal zone of arteriovenous malformations // International Journal of Clinical Neurosciences and Mental Health, 2014, 1 (Suppl.1), P.119-125.

Semenyutin V. B., Pechiborsch D. A, Aliev V. A., Patzak A., Panuntsev G. K., Kozlov A. V. Collateral cerebral venous outflow by scalp veins in patients with parasagittal meningiomas // International Journal of Clinical Neurosciences and Mental Health, 2014, 1 (Suppl.1), P.153-158.

Nikitina T., Zavaritskaya O., Semenyutin V., Persson P.B., Patzak A., Sendeski M. Effects of contrast media on cerebral vasospasm in a novel model of subarachnoid haemorrhage // Arq. Neuro-Psiquiatr, 2015, Vol.73, N 2. P.125-131.

Semenyutin V. B.,  Asaturyan G. А.,  Nikiforova  А. А.,  Aliev V. A.,  Panuntsev  G. К.,  Iblyaminov V. B.,  Savello A. V. , Patzak А. Predictive value of dynamic cerebral autoregulation assessment in surgical management of patients with high-grade carotid artery stenosis // Frontiers in Phisiology. — November 2017, Vol.8, Art.872, 10 pgs, doi: 10.3389/fphys.2017.00872.

Аliev V.A., Semenyutin V.B. and Panuntsev G.K. Predictive Value of Cerebrovascular Reserve in Patients with Carotid Artery Stenosis for Choosing Treatment Strategy // International Journal of Pathology and Clinical Research, 2019, 5:086, Volume 5 | Issue 1 DOI: 10.23937/2469—5807/1510086 Open Access, 8 pgs.

Semenyutin V.B., Аliev V.A., Panuntsev G.K., Patzak A. Perioperative dynamics of intracranial B-waves of blood flow velocity in basal cerebral arteries in patients with brain arteriovenous malformation. Intracranial Pressure and Neuromonitoring XVII. Acta Neurochirurgica, Supplement. 2020, Vol. 131, P. 63-68.

G. Malykhina, V. Salnikov, V. Semenyutin, D. Tarkhov. Digitalization of medical services for detecting violations of cerebrovascular regulation based on a neural network signal analysis algorithm. SPBPU IDE '20: Proceedings of the 2nd International Scientific Conference on Innovations in Digital Economy: SPBPU IDE-2020, October 22-23, 2020, Saint — Petersburg, Russia. No.: 61. P. 1–7. doi.org/10.1145/3444465.3444526.

G.F. Malykhina, V.Y. Salnikov, V.B. Semenyutin. Neural network algorithm for the diagnosis of impaired cerebral autoregulation. НЕЙРОИНФОРМАТИКА-2020. XXII Международная научно-техническая конференция. Сборник научных трудов, 2020. P. 82-92.

Patents

Nikitin P. I., Panuntsev V. S. Semenyutin V. B., Alekseev V. V., Bukhaev I. M. Method for assessing the exclusion of brain arteriovenous malformation from the blood circulation. Bull. No. 7.2003, Patent for invention No. 2199944.

Govorov B. B., Asaturyan G. A., Semenyutin V. B., Panuntsev V. S., Aliev V. A., Alekseev V. V. Method of contact microvascular Doppler sonography, 2004. Patent for invention No. 2231978.

Semenyutin V. B., Nikitin P. I., Sergienko S. K., Bukhaev I. M. Method for determining the functional significance of the vessel of brain AVM. Bull. No. 4, 2005, Patent for invention No. 2245670.

Semenyutin V. B., Aliev V. A., Nikitin P. I., Kozlov A. V. Method for diagnosing impaired cerebral blood flow autoregulation. Bull. No. 3, 2006, Patent No. 2269300.

Manukovsky V. A., Govorov B. B., Svistov D. V., Semenyutin V. B., Kravtsov M. N., Kozlov A. V. Device for the delivery of viscous formulations into the vertebral bodies, brain vascular malformations. Bull. No. 10, 2008, Patent for utility model No. 72136.

Semenyutin V. B., Aliev V. A., Bersnev V. P., Kozlov A. V. Method for diagnosing the functional significance of the afferent vessel of brain arteriovenous malformations. Bull. No. 29, 2008, Patent for invention No. 2336017.

Semenyutin V. B., Aliev V. A. Method for diagnosing the functional significance of the internal carotid artery, 2014, Patent for invention No. 2529379.

Semenyutin V. B., Panuntsev G. K., Aliev V. A. Method for assessing the degree of vascular occlusion of intracranial pathological arteriovenous cerebral bypass from the blood circulation, 2014, Patent for invention No. 2522964

Semenyutin V. B., Aliev V. A., Bersnev V. P., Panuntsev G. K., Ramazanov Sh.Sh., Method for determining indications for surgical treatment of normotensive hydrocephalus, 2014, Patent for invention No. 2525730.

Semenyutin V.B., Aliev V.A., Panuntsev G.K., Nikiforova A.A. Method for determining the functional significance of stenosis of the internal carotid artery. RF patent No. 2588323. 2016.

Patent No. 2598758, issued on 06.09.2016, application No. 2015122668 dated 10.06.2015, published on 27.09.2016, Bull. No. 27.
Method for predicting hemorrhagic complications after exclusion of cerebral arteriovenous malformation from the blood flow
Authors: Semenyutin V.B., Aliev V.A. ogly, Panuntsev G.K., Nikiforova A.A.

Semenyutin V.B., Govorov B.B., Panuntsev G.K., Aliev V.A. Method for continuous monitoring of the linear velocity of blood flow in the internal carotid artery, 2018. RF patent 2678685.

Patent No. 2734994 issued on 27.10.2020, application No. 2020101137 dated 10.01.2020
Method for determining the hemodynamic significance of stenosis of the internal carotid artery
Authors: Semenyutin V.B., Nikiforova A.A., Panuntsev G.K., Aliev V.A.