Director of the Centre
The Preclinical Translational Research Centre is a new facility of Almazov Centre conducting a wide range of state-of-the-art scientific and preclinical studies in accordance with all international standards.
The Preclinical Translational Research Centre is equipped and staffed to handle a full cycle of high-tech basic and applied research in various fields of biomedical science, including the study of the mechanisms underlying the onset and progression of socially significant diseases, the development of new methods for their prevention, diagnosis and treatment as well as the development and validation of various disease experimental models, from in silico to in vivo.
The facility comprises a Testing Centre complying with the principles of Good Laboratory Practice (GLP).
The Testing Centre carries out preclinical studies of biological, biosimilar and synthesized drugs, medical devices, medical technologies and biomedical cell products, from the development of technical specifications and preclinical study design to the transfer of a complete reporting package and relevant documentation as required for the master file.
The Centre provides a range of services for preclinical studies including studies to assess the safety and efficacy of drugs and medical devices as well as those related to structural and functional characteristics, pharmacokinetics, pharmacodynamics and bioavailability of drugs. It has more than 500 units of the most advanced analytical equipment to conduct clinical, diagnostic, physicochemical, pathomorphological, immunochemical, physiological, cytological and molecular studies at the highest level of excellence.
The Testing Centre testing has veterinary, pharmacological, engineering services, research laboratories and a support unit for preclinical research.
The Centre has a nursery for laboratory rodents with vivariums and areas for larger animals (minipigs, swine) and aquatic animals (Danio rerio and Xenopus laevis species). The Department of Biological Test Systems and Models is equipped to generate genetically modified rodents (transgenic and knockout mice) and fish. In the area for larger animals there is an operating unit fully equipped to perform both training procedures (including robotic-assisted surgery with the daVinci® Surgical System) and preclinical studies to assess the safety and efficacy of medicines.
The Preclinical Translational Research Centre is a site for educational and research activities carried out by the Institute of Experimental Medicine, the Institute of Medical Education, the clinic and other divisions of Almazov Centre.
- Research Department of Toxicology
- Research Department of Pathology
- Research Department of Biochemistry
- Research Department of Experimental Physiology and Pharmacology
- Chemical Analysis Research Department
- Research Department of Pulmonary Circulation Disorders
- Research Laboratory of Infectious Pathogens and Biomolecular Nanostructures