Division of Experimental Physiology and Pharmacology

 
Vitaly Tsyrlin
Head of the Division, Professor

Division of Experimental Physiology and Pharmacology was set up when the Federal Almazov North-West Medical Research Centre (former Almazov Federal Heart, Blood and Endocrinology Centre) was founded.

Basic Research Directions:

Research in our Division focuses on the physiology and pharmacology of central regulatory mechanisms of blood flow. The research results allow us to formulate the concept that reduction of high blood pressure by centrally acting agents can be successful only when they are able to effect on tonic activity of sympathetic vasomotor neurons. Mechanisms of increase in blood pressure induced by aversive emotiogenic stimuli have been demonstrated for the first time. Researchers of the Division have proved that the mechanism of increase in blood pressure in both negative and positive emotions is mediated by activation of different types of central regulatory mechanisms.

Some studies performed by Division’ researchers were aimed at questions of neurochemical organization of central regulatory mechanisms. It has been proved that functional activities of imidazoline systems are higher in animal models of arterial hypertension than in normotensive animals. Studies have revealed that imidazoline systems are also involved in the functioning of central pathway of baroreceptor reflex. Imidazoline receptors are involved not only in activation of baroreceptor reflex arc at the bulbar level, but also in suprabulbar modulation processes of the reflex mediated by emotional stress.

In addition, an intensive research of the nervous regulation of trophic processes in the heart muscle and dependency of tissue disorders from changes in the functions of both central and peripheral nervous system was performed in the last years. It has been shown that catecholamine influences not only on the structural changes in the myocardium, but also causes morphological disorders of vascular smooth muscle.

Attempts to influence the development of target organ damage processes in the spontaneously hypertensive rats during the early postnatal period as an adequate model of human hypertension were made in experiments performed in the Division. It has been proved that reduction of the sympathetic activity in the prenatal and early postnatal periods inhibits the development of hypertension and prevents vascular remodeling of resistance vessels in an animal model.

Studies of recent years were designed to explore the role of arterial baroreceptor reflex in the long-term control of blood pressure. Researchers of the Division have demonstrated that arterial baroreceptor reflex is involved in the long-term regulation of blood pressure and inhibited its long-term increase in response to a stimulus.

Key achievements and results of the Division

Research at the moment and development prospects

Participation in scientific programs and Government Projects

Key publications of the Division

Tsyrlin V. A., Bravkov M. F. Effects of alpha-adrenoceptor stimulating drugs on baroreceptor reflex in conscious cats // Eur. J. Pharmacol. – 1980. – Vol. 67. – P. 75-83.

Tsyrlin V. A., Bravkov M. F. Bershadsky B. G. Possible mechanisms underlying the pressure responses evoked in conscious cats by emotional stress // Pflugers Arch. – 1983. – B. 398. – S. 81-87.

Tsyrlin V. A., Pliss M. G., Patkina N. A., Bershadsky B. G., Eremeev V. S. Baroreceptor reflex inhibition as a mechanism for raising blood pressure under negative emotions / In: Systems Research in Physiology // Amsterdam: Gordon and Breach Science Publishers. – 1989. – Vol. 3. – P. 329-341.

Penniyainen V. A., Lopatina E. V., Krylov B. V. The effect of sodium pump inhibitors on sensory ganglion neurite growth // Neurosciences and Behavioral Physiology. – 2009. – Vol. 39. – № 3. – P. 301-305.