Pediatric Endocrinology Laboratory

Irina Nikitina, MD, DSc
Head of Laboratory

The laboratory focuses on the research of age-dependent features in the diagnosis and treatment of endocrine disorders to enhance the quality of medical care for children and adolescents with endocrine diseases.

Ongoing research:

  • Diabetes mellitus in children
    Developing new diagnostic methods for diabetes and its complications in children to optimize the correction of metabolic disorders and genetic prediction. Expected outcomes: characterization of etiological variants of diabetes in children, development of algorithms for differential diagnosis and prediction of genetic diabetes, development of individual follow-up protocols depending on the etiology of DM.
  • Studying the epidemiology of vitamin D-deficient conditions in children and adolescents in the north-western region of the Russian Federation
    Studying the bone mineral density in children with endocrine disorders. Expected outcomes: vitamin D provision in pediatric population of the north-western region; developing the ways to correct vitamin D deficiency and disorders of mineral metabolism in the pediatric population and in endocrine disease.
  • Clinical and laboratory characteristics and new technologies development for children and adolescents with hyperandrogenic syndrome
    Expected outcomes: improved methods of differential diagnosis of various hyperandrogenic conditions and methods for their management.
  • Subclinical thyroid dysfunction in children and adolescents
    Expected outcomes: studying the effect of subclinical hypo- and hyperthyroidism on central nervous system, bone metabolism, cardiovascular system, and metabolism in children; creating a follow-up algorithm based on the nature and extent of thyroid gland functional disorders.
  • Genotype-phenotype correlation in congenital hyperinsulinism
    Specific features of the disease course depending on the identified mutations; long prospective study of physical and neuro-psychological development of children receiving comprehensive treatment for congenital hyperinsulinism. The research also focuses on sex development disorders. Phenotypic characteristics are compared with the presence of tissue-specific mosaicism of sex chromosomes and the nature of SRY gene expression.

The laboratory closely collaborates with universities and clinics in Germany, Sweden, etc.

Participation in scientific events

Clinical practice  

Training and education 

Major publications:

Nikitina I. L., Baranova T. I. Influence of prevention of iodine deficiency disorders in pregnant women on mental and somatic health their children//A Cochrane Review Journal – 2011. — Vol. 6 (S1). — P. 87.

Nikitina I. L., Kostareva A. A., Grineva E. N. et al. Case of Permanent Neonatal Diabetes Mellitus Caused by Y330H KCNJ11 Gene Mutations: Genotype-Phenotype Correlations//Diabetes (Suppl.1) – 2013.

Nikitina I. L., Artemeva I. Y., Kostareva A. A., Mitrophanova L. B., Grineva E. N. The case of severe congenital hyperinsulinism and undermusculinization in a boy. – Abstract Book of International Workshop on Multiple Endocrine Neoplasia, Belgium, September 5-8th 2012.

Nikitina I. L., Bairov V. G., Chegoleva N. A., Gurkina E. Y., Artemeva I. Y., Kostareva A. A., Grineva E. N., Mitrophanova L. B. The combination of congenital hyperinsulinism and disorder of sex development in 5-month infant //Abstract book of Symposium «Monogenic Disorders of Insulin Secretion», Philadelphia, 2012, March, 15-16 — P. 18.

Nikitina I. L., Ditkovskaya L. V., Skorodok Y. L., Demchuk Y. A., Todieva A. M. Assessment of efficiency insulin pump therapy in school-age children with type 1 diabetes. – Abstract Book of 51th Annual Meeting of ESPE, Leipzig, 20-23th September 2012, P. 262.