Scientific Laboratory of Pediatric Endocrinology

 
Irina Nikitina
Laboratory head, MD

The laboratory focuses on the research of age-dependent features in diagnosis, treatment and pathology of endocrine organs for the purpose of improving the quality of medical care for children and adolescents with endocrine diseases.

Ongoing research:

  • Diabetes mellitus in children
    We developed new diagnosis methods for diabetes and its complications in children to optimize the correction of metabolic disorders and genetic prediction. Expected outcome: characterization of diabetes etiological variants in children, development of algorithms for differential diagnosis and prediction of genetic diabetes, development of individual protocols for children watching, depending on the etiology of diabetes.
  • Study of vitamin D deficiency states epidemiology in children and adolescent population of the north- western region of the Russian Federation.
    Study of bone mineral density in children with disorders of endocrine organs. Expected outcomes: vitamin D provision in pediatric population of the north- western region of Russia; vit. D deficiency, disorders of mineral metabolism, and disease of endocrine system correction.
  • Clinical and laboratory characteristics and new technologies development for children and adolescents with hyperandrogenic syndrome. Expected outcomes: improved methods of differential diagnosis of various hyperandrogenic syndrome forms and its correction.
  • Subclinical thyroid dysfunction in children and adolescents.
    Expected outcomes: study the effect of subclinical hypothyroidism and hyperthyroidism on central nervous system, bone metabolism, cardiovascular system, and metabolism in children. We plan to create an algorithm of children watching, depending on the nature and extent of thyroid gland functional disorders.
  • “Genotype-phenotype” correlation in congenital hyperinsulinism.
    Features of the disease course depending on the options of identified mutations; long prospective study of physical, neuro- psychological development of children who received combined congenital hyperinsulinism therapy. The research subject is the study of sex disorders formation as well. We compare phenotypic characteristics with the presence of tissue mosaicism variants of sex chromosomes, and the nature of SRY- gene expression.

Scientific Laboratory of Pediatric Endocrinology has rich and fruitful international cooperation with universities and clinics in Germany, Sweden, etc.

Participation in scientific events

Therapeutic activity

Laboratory staff key publications:

Nikitina I. L., Baranova T. I. Influence of prevention of iodine deficiency disorders in pregnant women on mental and somatic health their children//A Cochrane Review Journal – 2011. — Vol. 6 (S1). — P. 87.

Nikitina I. L., Kostareva A. A., Grineva E. N. et al. Case of Permanent Neonatal Diabetes Mellitus Caused by Y330H KCNJ11 Gene Mutations: Genotype-Phenotype Correlations//Diabetes (Suppl.1) – 2013.

Nikitina I. L., Artemeva I. Y., Kostareva A. A., Mitrpphanova L. B., Grineva E. N. The case of severe congenital hyperinsulinism and undermusculinization in a boy. – Abstract Book of International Workshop on Multiple Endocrine Neoplasia, Belgium, September 5-8th 2012.

Nikitina I. L., Bairov V. G., Chegoleva N. A., Gurkina E. Y., Artemeva I. Y., Kostareva A. A., Grineva E. N., Mitrophanova L. B. The combination of congenital hyperinsulinism and disorder of sex development in 5-month infant.//Abstract book of Symposium «Monogenic Disorders of Insulin Secretion», Philadelphia, 2012, March, 15-16 — P. 18.

Nikitina I. L., Ditkovskaya L. V., Skorodok Y. L., Demchuk Y. A., Todieva A. M. Assessment of efficiency insulin pump therapy in school-age children with type 1 diabetes. – Abstract Book of 51th Annual Meeting of ESPE, Leipzig, 20-23th September 2012, P. 262.