Laboratory for Surgery of Metabolic Disorders

 

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The Research Laboratory for Surgery of Metabolic Disorders was established as part of the Institute of Endocrinology.

Major objectives

  • Studying the possibility of predicting the outcomes of bariatric surgery.
  • Justifying and assessing the systemic effects of bariatric surgery on the components of metabolic syndrome.
  • Developing and implementing the concept of personalized medicine based on the assessment of genetically determined and phenotypic changes using clinical expert systems in the surgical treatment of patients with metabolic syndrome and type 2 DM.
  • Justifying the surgical methods for incretin disorders in type 2 DM in patients with a BMI of less than 35 kg/m2.
  • Preventing and developing new methods for the treatment of instrumental suture failure in longitudinal gastric resection.
  • Studying the mechanisms for correction of obesity and metabolic disorders using gut microflora.
  • Developing the recommendations for the surgical treatment of patients with obesity and diabetes mellitus, training of specialists in the Bariatric Surgery specialty.
Alexander Neumark, MD, PhD
Head of Laboratory

Training and education

  • Annual scientific and practical workshop Surgical Treatment of Obesity and Metabolic Disorders
  • Practical courses on bariatric surgery
  • Awareness-raising project Overweight School
  • Organization of international and regional conferences on surgery of obesity and metabolic syndrome

Participation in State Assignments 

State assignment of the Russian Ministry of Health on the topic: “Development of an automated system for choosing a treatment method for type 2 diabetes mellitus”, supervised by: E. N. Grineva

Grants

Development of personalized therapy for obesity and type 2 diabetes mellitus to reduce cardiovascular risks.
Grant supervisor: E.V. Shlyakhto, Director General.
Completion date: 31.12.2020.
The specialists of the Laboratory have been involved in research supported by the grant from 2017 to 2020.

Major publications

Sanches E., Timmermans M., Pouwels S., Topal B., Celik A., Sundbom M., Ribeiro R., Parmar C., Ugale S., Proczko M., Stepaniak P.S., Pujol Rafols J., Mahawar K., Buise M.P., Neimark A., Severin R. Cardiac remodeling in obesity and after bariatric and metabolic surgery; is there a role for gastro-intestinal hormones? Expert Review of Cardiovascular Therapy. 2019. Nov;17 (11):771-790. IF 1,90

Timofte D., Stoian A.P., Hainarosie R., Diaconu C., Iliescu D.B., Ciuntu B., Iordache N., Neimark A. Взаимосвязь между употреблением алкоголя и потерей веса после бариатрических операций. Эндоскопическая хирургия. 2018. Т. 24. № 6. С. 33-39. IF 0,274

Effect of gene-lifestyle interaction on gestational diabetes risk. Popova P.V., Klyushina A.A., Vasilyeva L.B., Tkachuk A.S., Bolotko Y.A., Gerasimov A.S., Pustozerov E.A., Kravchuk E.N., Kostareva A.A., Grineva E.N., Predeus A. Oncotarget. 2017. Т. 8. № 67. С. 112024-112035

Fasting glycemia at the first prenatal visit and pregnancy outcomes in russian women Popova P., Tkachuk A., Dronova A., Gerasimov A., Kravchuk E., Grineva E., Bolshakova M., Rozdestvenskaya O., Demidova K., Nikolaeva A. Minerva Endocrinologica. 2016. Т. 41. № 4. С. 477-485

Patents and inventions

Patent No. 2707377 “Method of intraoperative visualization of the instrumental suture failure in longitudinal gastric resection.
Authors: A.A. Kovalev, O.V. Kornyushin, G.V. Papayan, V.V. Masley, N.I. Bulavinova, A.E. Neumark, I.N. Danilov, S.E. Voronin

Contacts:
Alexander Neumark, Leading Researcher
E-mail: sas_spb@mail.ru