Laboratory of Endocrine Diseases in Pregnancy

 

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Polina Popova, MD, PhD
Head of Laboratory

Major research areas

  • Study of molecular, genetic and epigenetic basis for the development of gestational diabetes mellitus (GDM) and its effect on the fetus.
  • Development of the optimal treatments for GDM, including customization of target glycemic levels, optimization of dietary recommendations and development of personalized therapy for women with GDM.
  • Development and introduction of telemedicine technologies for the treatment of patients with diabetes and obesity.
  • Study of the pathogenetic mechanisms underlying metabolic complications and cardiovascular disease in women with polycystic ovary syndrome (including changes in the microbiome and molecular genetic aspects) and the development of methods for their prevention.
  • Study of the association between thyroid function and iodine supply values before and during pregnancy with adverse pregnancy consequences and outcomes in children in order to optimize recommendations for their prevention.

Participation in State Assignments

“Study of the association between thyroid function and iodine supply values before and during pregnancy with adverse pregnancy consequences and outcomes in children in order to optimize recommendations for their prevention” (2020—2022, supervisor: Polina Popova).

“Studying the effect of different weight loss strategies on fertility and microbiome in women with obesity and polycystic ovary syndrome (2018—2020, supervisor: Polina Popova).

“The search for new biomarkers predicting the risk of gestational diabetes and the development of methods for its prevention in high-risk groups”  (2011—2014, supervisor: Elena Grineva).

“Development of a method for early detection of gestational diabetes mellitus” (2011, supervisor: Elena Grineva).

Major scientific achievements

As a result of joining the international Consortium on Thyroid and Pregnancy, the findings combined from many studies proved the association of mild thyroid dysfunction and increased antibody titer to various thyroid components with preterm birth (Consortium on Thyroid and Pregnancy — Study Group on Preterm Birth. Association of Thyroid Function Test Abnormalities and Thyroid Autoimmunity With Preterm Birth. A Systematic Review and Meta-analysis. JAMA. 2019 20;322 (7):632-641). These data support the recommendations of the American Thyroid Association about the need for different target levels of thyroid stimulating hormone (TSH) in pregnancy depending on the level of antibodies to thyroid peroxidase (TPOAb).

In the course of the “Study of the molecular, genetic and epigenetic mechanisms for the development of gestational diabetes mellitus and its effect on the fetus” supported by the grant from the Russian Science Foundation (No. 15-14-30012), the effect of gene-lifestyle interaction on the development of gestational diabetes was proved. It has been shown that the association between sausage consumption and the risk of developing GDM depends on the number of risk alleles in rs10830963 in the MTNR1B gene and rs1799884 in the GCK gene (Popova PV, et al. Effect of gene-lifestyle interaction on gestational diabetes risk. Oncotarget. 2017, 8: 112024-112035).

New approach to cryopreservation of primary non-cultivated human umbilical vein endothelium was developed (Puzanov MV, Vasilyeva LB, Popova PV, et al. New approach to cryopreservation of primary non-cultivated human umbilical vein endothelium in biobanking. Biopreservation and Biobanking, 2018).

The study showed differences in the expression of a number of genes between the patients with gestational diabetes and those in the control group, including genes involved in the development of endothelial dysfunction (Popova P. et al. A Randomised, Controlled Study of Different Glycaemic Targets during Gestational Diabetes Treatment: Effect on the Level of Adipokines in Cord Blood and ANGPTL4 Expression in Human Umbilical Vein Endothelial Cells. International Journal of Endocrinology. Vol. 2018, Article ID 6481658, 8 pages, 2018). The study also established the dependence of TRIB gene expression in umbilical vein endothelial cells on the duration of intrauterine hyperglycemia exposure (Popova P, et al. Association of tribbles homologue 1 gene expression in human umbilical vein endothelial cells with duration of intrauterine exposure to hyperglycaemia Genet. Res., Camb. (2018), 100, pp. 1–9).

A mobile application and mathematical models were developed for predicting blood glucose levels in response to meals for patients with GDM  (E. Pustozerov, P. Popova, `et al. Mobile personalized blood glucose prediction system for patients with gestational diabetes mellitus. JMIR mHealth and uHealth. 2018; 6 (1)).

The Federal Service for Surveillance in Healthcare issued the permission to use newly developed medical technology entitled “A method for predicting the effectiveness of treatment improving insulin sensitivity in patients with polycystic ovary syndrome.”

Grants

  • Study of predictors of postprandial glycemic response and the need for insulin therapy in women with gestational diabetes mellitus in order to personalize approaches to its treatment. (to be completed in 2021, grant supervisor: E.A. Pustozerov).
  • Study of molecular, genetic and epigenetic mechanisms for the development of gestational diabetes mellitus and its effect on the fetus  (completed in 2017, grant supervisor E.N. Grineva).
International collaboration

2019 — Memorandum of Understanding  between Almazov Centre and the University of Arkansas, USA within the Consortium on Thyroid and Pregnancy (project leader, Russia: Polina Popova).

2018—2019 “Estimating iodine intake from spot urinary iodine concentrations to obtain the prevalence of inadequate or excess usual iodine intake in school-aged children and adults”, jointly with the Laboratory of Human Nutrition, ETH Zurich, Switzerland (project leader, Russia: Polina Popova).

2017—2018 “Assessment of dried blood spot thyroglobulin in pregnant women to redefine the range of median urinary iodine concentration that indicates adequate iodine intake (STRIPE)”, jointly with the Laboratory of Human Nutrition, ETH Zurich, Switzerland (project leader, Russia: Polina Popova).

2017—2019 “Study of the impact of diet on the microbiome of women with polycystic ovary syndrome”, jointly with Bar-Ilan University, Israel (project leader, Russia: Polina Popova).

2017 — “Study of new biomarkers and epigenetic mechanisms for the development of gestational diabetes mellitus and preeclampsia”, jointly with Tel Aviv University, Israel (project leader, Russia: Polina Popova).

Major publications

Derakhshan, A., Peeters, R. P., Taylor, P. N., Bliddal, S., Carty, D., Meems, M., Vaidya, B., Chen, L., Knight, B., Ghafoor, F., Popova, P. V., Mosso, L., Oken, E., Suvanto, E., Hisada, A., Yoshinaga, J., Brown, S. J., Bassols, J., Auvinen, J., Bramer, W. M., López-Bermejo, A., Dayan, C. M., French, R., Boucai, L., Vafeiadi, M., Grineva, E. N., Pop, V. J.M., Vrijkotte, T. G., Chatzi, L., Sunyer, J., Jiménez-Zabala, A., Riaño, I., Rebagliato, M., Lu, X., Pirzada, A., Männistö, T., Delles, C., Feldt-Rasmussen, U., Alexander, E. K., Nelson, S., Chaker, L., Pearce, E. N., Guxens, M., Steegers, E. A.P., Walsh, J. P., and Korevaar, T. I.M. Association of maternal thyroid function with birth weight: a systematic review and individual-participant data meta-analysis. Lancet Diabetes Endocrinol 2020; 8: 501–10 https://doi.org/10.1016/ S2213—8587 (20) 30061-9 IF 24.540

Pustozerov, E.; Tkachuk, A.; Vasukova, E.; Dronova, A.; Shilova, E.; Anopova, A.; Piven, F.; Pervunina, T.; Vasilieva, E.; Grineva, E.; Popova, P. The Role of Glycemic Index and Glycemic Load in the Development of Real-Time Postprandial Glycemic Response Prediction Models for Patients With Gestational Diabetes. Nutrients 2020, 12, 302. doi: 10.3390/nu12020302. IF 4.171

Consortium on Thyroid and Pregnancy—Study Group on Preterm Birth, Korevaar TIM, Derakhshan A, Taylor PN, Meima M, Chen L, Bliddal S, Carty DM, Meems M, Vaidya B, Shields B, Ghafoor F, Popova PV, Mosso L, Oken E, Suvanto E, Hisada A, Yoshinaga J, Brown SJ, Bassols J, Auvinen J, Bramer WM, López-Bermejo A, Dayan C, Boucai L, Vafeiadi M, Grineva EN, Tkachuck AS, Pop VJM, Vrijkotte TG, Guxens M, Chatzi L, Sunyer J, Jiménez-Zabala A, Riaño I, Murcia M, Lu X, Mukhtar S, Delles C, Feldt-Rasmussen U, Nelson SM, Alexander EK, Chaker L, Männistö T, Walsh JP, Pearce EN, Steegers EAP, Peeters RP. Association of Thyroid Function Test Abnormalities and Thyroid Autoimmunity With Preterm Birth. A Systematic Review and Meta-analysis. JAMA. 2019;322 (7):632-641 DOI:10.1001/jama.2019.10931 IF 47.661

Popova , L. Vasilyeva, A. Tkachuck, M. Puzanov, A. Golovkin , Y. Bolotko, E. Pustozerov, E. Vasilyeva, O. Li, I. Zazerskaya, R. Dmitrieva, A. Kostareva, E. Grineva. A Randomised, Controlled Study of Different Glycaemic Targets during Gestational Diabetes Treatment: Effect on the Level of Adipokines in Cord Blood and ANGPTL4 Expression in Human Umbilical Vein Endothelial Cells. International Journal of Endocrinology 2018, Article ID 6481658, ИФ 2,340

Pustozerov, P. Popova, A. Tkachuk, Y. Bolotko, Z. Yuldashev, E. Grineva. Mobile personalized blood glucose prediction system for patients with gestational diabetes mellitus. JMIR mHealth and uHealth. 2018; 6 (1): e6. doi: 10.2196/mhealth.9236. ИФ 4,636

Popova P,  Vasileva L, Tkachuck A, Puzanov M,  Bolotko Y, Pustozerov E, Gerasimov A, Zazerskaya I, Li O, Vasilieva E, Kostareva A, Dmitrieva R, Grineva E. Association of tribbles homologue 1 gene expression in human  umbilical vein endothelial cells with duration of intrauterine exposure to hyperglycaemia Genet. Res., Camb. (2018), 100, pp. 1–9. © Cambridge University Press 2018 doi:10.1017/S0016672318000010  IF 1,059

Puzanov MV, Vasilyeva LB, Popova PV, Grineva EN, Dmitrieva RI. New approach to cryopreservation of primary non-cultivated human umbilical vein endothelium in biobanking. Biopreservation and Biobanking. 2018; 16 (2):114-119. doi: 10.1089/bio.2017.0086 ИФ 1,698

Popova PV, Klyushina AA, Vasilyeva LB,  Tkachuk AS, Bolotko YA, Gerasimov AS, Pustozerov EA, Kravchuk EN, Predeus A, Kostareva AA, Grineva EN.  Effect of gene-lifestyle interaction on gestational diabetes risk. Oncotarget. 2017, 8: 112024-112035 ИФ 5,168

Popova P, Tkachuk A, Bolotko YA, Gerasimov AS, Demidova KA, Pustozerov, Kuznetsova LV, Grineva EN. Risk of gestational diabetes mellitus: Which lifestyle parameters should be changed? Diabetes Mellitus. 2017; 20 (1); 85-92 (ИФ РИНЦ 2,397)

Patents

Patent for Invention No. 2427842 with the Federal Agency for Intellectual Property, Patents and Trademarks.
“Method for predicting the effectiveness of treatment for patients with polycystic ovary syndrome with metformin and / or by weight loss”
Authors: P.V. Popova, E.N. Grineva, I.E. Zazerskaya, E.M. Ryazantseva, E.V. Shlyakhto.

Contacts:
Polina Popova, Head of Laboratory
E-mail: pvpopova@yandex.ru