Clinical Endocrinology Laboratory

 
Tatyana Karonova, MD, DSc
Laboratory Head

Ongoing research areas:

  • The role of vitamin D deficiency in the pathogenesis of extraskeletal metabolic disorders in children and adults.
    These studies have been conducted since 2012. The researchers of the Centre have established the contribution of vitamin D deficiency and individual polymorphisms of the vitamin D receptor gene to the development of certain components of the metabolic syndrome. The studies are ongoing to evaluate the role of vitamin D in children and adults with obesity and diabetes. Supraphysiological doses of vitamin D have been shown to have a positive effect on the indicators of microcirculation and inflammation in patients with type 2 diabetes and diabetic neuropathy. The specialists of the Centre co-authored the clinical guidelines for the diagnosis, prevention and treatment of vitamin D deficiency in adults and the National Programme “Vitamin D deficiency in children and adolescents of the Russian Federation: modern approaches to correction” proposed by the Russian Association of Endocrinologists, the Russian Association of Pediatricians and the Russian Association for Osteoporosis. The results of research in this area are presented annually at Russian and international congresses, including ECE, EASD, ADA, ESPE, WCO-IOF-ESCEO.
  • Developing new drugs based on salts of succinic acid for the treatment of osteoporosis
    Researchers continue their efforts on creating a novel drug for the treatment of osteoporosis based on salts of succinic acid. The results of preclinical trials have demonstrated efficacy and non-toxicity of this drug. A clinical and experimental study is conducted to examine the mechanisms of bone remodeling disorders in hyperglycemia and the effect of various types of sugar-lowering drugs. Jointly with the specialists of the Laboratory for Surgery for Metabolic Disorders, the researchers are studying the effect of various types of bariatric surgery on bone remodeling markers.
  • Studying prognostic markers and differential diagnosis of various types of amiodarone-induced thyrotoxicosis
    Following the State Assignment for 2018—2010, the researchers have been searching for differential diagnostic criteria for types 1 and 2 amiodarone-induced thyrotoxicosis and an automated decision-making system is being developed.
  • Studying the role of kisspeptins in the genesis of delayed sexual development in boys of puberty age
    Based on clinical and experimental studies, kisspeptin mechanisms of sex regulation are studied and new techniques for treating sexual development disorders are being developed.
  • Studying the incidence of parathyroid gland disease and impaired cardiovascular remodeling in hypo- and hyperparathyroidism
    The Centre has all the facilities for advanced examination and comprehensive treatment of patients with parathyroid gland disease. It is not only a leading medical facility providing medical care for patients with hypo- and hyperparathyroidism, but also a scientific centre conducting research in this field.
  • Conducting clamp studies in healthy volunteers and type 1 diabetic patients
    Within the framework of the memorandum on cooperation, the specialists of the Research Laboratory use the hyperinsulinemic-euglycemic clamps in patients with type 1 DM and healthy volunteers using domestic biosimilar insulins of various durations.
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Participation in scientific events

Clinical practice

Our specialists provide consultation, diagnostic and treatment services to patients at the Endocrinology Department of Almazov Centre as well as at the endocrinology divisions of Pavlov State Medical University.

They participate in the annual endocrinology workshop, diabetes insipidus workshop, clinical case discussions of diabetes insipidus.