Research Department for CVDs in Children/Research Group for Pediatric Cardiac Surgery

 
Elena Vasichkina, MD, DSc
Chief Researcher, Pediatric Cardiologist, Board Certified

The Research Department for CVDs in Children/Research Group for Pediatric Cardiac Surgery was established in May 2017.

The activities of the Department relate to basic and applied research aimed at developing and improving methods for the prevention, diagnosis and treatment of cardiovascular disease (CVD) in children.

Major focus areas

  • Inflammatory myocardial diseases
  • Cardiomyopathies
  • Congenital and acquired heart defects
  • Molecular and genetic basis of heart rhythm and conduction disorders
  • Etiological and pathomorphological features of progressive heart rhythm and conduction disorders
  • Fetal cardiology and arrhythmology, severe heart failure
  • Management of patients before and after heart transplantation
  • Rehabilitation of patients with heart disease and after surgery for CHD
  • Pulmonary hypertension
  • Syncopal conditions

Ongoing research

Basic research: “Personalized medicine in choosing a strategy for the diagnosis and treatment of heart failure due to heart remodeling in congenital heart defects, arrhythmias and genetically determined myocardial diseases in children”.

Clinical trials

  • Clinical testing “Use of immunomodulatory therapy in children with inflammatory myocardial diseases” (2015—2018).
  • Clinical testing “Personalized therapy for chronic heart failure in children with cardiomyopathies based on pharmacogenetics using a new generation sequencing technology for genetic verification of the diagnosis” (2016—2017).

In 2017–2019, the specialists of the Department published 23 articles in peer-reviewed journals, 4 monographs and 1 patent.

Participation in international conferences

In the past 3 years, research specialists took part in 14 international congresses with 25 presentations and in 35 Russian conferences with 75 presentations.

The specialists of the Department are members of Russian and international professional societies including the All-Russian Association of Pediatric Cardiologists, Russian Society of Cardiology, All-Russian Scientific Society of Arrhythmologists, European Society of Cardiology (ESC), European Heart Rhythm Association (EHRA), and Heart Failure Association (HFA).

Clinical practice

All specialists of the Department are highly qualified and board certified cardiac surgeons, cardiologists and pediatricians. Their clinical sites are: Department of Cardiovascular Surgery for Children, Department of Pediatric Cardiology and Medical Rehabilitation, Cardiac Intensive Care Unit, Neonatal Disease Unit.

Training and education

The specialists deliver annual educational cycles for doctors specializing in Pediatric Cardiology, courses on clinical and interventional arrhythmology, critical congenital heart defects (CHD), and myocardial diseases.

Presentations and posters at international conferences (2017–2019)
  1. The role of endomyocardial biopsy in establishing the etiology of progressive ventricular arrhythmias in children / E. S. Vasichkina, L. B. Mitrofanova, R. B. Tatarsky [et al.] // 51 Annual Meeting of the Association for European Paediatric and Congenital Cardiology 2017 (Lion, France, 29 March — 1 April 2017).
  2. Clinical course of myocarditis complicated by atrioventricular block in young children / E. S. Vasichkina, N. M. Boldina, T. M. Pervunina [et al.] // 51 Annual Meeting of the Association for European Paediatric and Congenital Cardiology 2017 (Lion, France, 29 March — 1 April 2017).
  3. Clinical course and electrophysiological characteristics of bimodal disease at children with implanted pacemakers / T. M. Pervunina, E. S. Vasichkina, D. F. Egorov [et al.] // 7th World Congress of Pediatric Cardiology and Cardiac Surgery (Barcelona, Spain 16–21 July 2017).
  4. Staged repair of pulmonary atresia, ventrical septal defect and major aorto-pulmonary collateral arteries with severe hypoplasia or absence of pulmonary arteries / A. A. Morosov, E. V. Grechov, R. R. Movsesian // 7th World Congress of Pediatric Cardiology and Cardiac Surgery (Barcelona, Spain, 16–21 July 2017).
  5. Importance endomyocardial biopsy to established etiology progressive arrhythmias in children / T. S. Loevets, L. B. Mitrofanova, R. B. Tatarsky, [et al.] // ESC Congress 2017 (Barcelona, Spain, 26–30 August 2017).
  6. Integrated model for the risk assessment of the unfavourable course of bimodal pathology in children / E. S. Vasichkina, T. M. Pervunina, T. M. Kruchina [et al.] // 52 Annual Meeting of the Association for European Paediatric and Congenital Cardiology 2018 (Athens, Greece, 9–12 May 2018).
  7. Use, effectiveness and safety of Ivabradine in paediatric patients with atrial tachycardia / T. S. Loevets, T. M. Pervunina, L. Butish [et al.] // 52 Annual Meeting of the Association for European Paediatric and Congenital Cardiology 2018 (Athens, Greece, 9–12 May 2018).
  8. Analysis of Notch pathway activity in cardiac progenitor cells of the patients with congenital heart defects / I. A. Kozyrev, E. V. Ignatieva, A. S. Golovkin [et al.] // 52 Annual Meeting of the Association for European Paediatric and Congenital Cardiology 2018 (Athens, Greece, 9–12 May 2018).
  9. A rare case of truncus arteriosus with right pulmonary artery arising from brachiocephalic trunk / A. Morozov, E. Grekhov, A. Latypov [et al.] // 26th Annual Meeting of the Asian Society for Cardiovascular and Thoracic Surgery — ASCVTS-2018 (Moscow, Russia, 24–27 May 2018).
  10. A fatal case of the Barth Syndrome in 1-year-old boy / T. S. Loevets, N. M. Boldina, E. V. Yakovleva [et al.] // The World Congress on Acute Heart Failure, (Vienna, Austria, 26–29 May 2018).
  11. Tachycardia-induced cardiomyopathy in children / E. Yakovleva, T. S. Loevets, T. L. Vershinina [et al.] // The World Congress on Acute Heart Failure (Vienna, Austria, 26–29 May 2018).
  12. Diagnosis and treatment of postoperative junctional ectopic tachycardia in Single center experience / E. S. Vasichkina, T. L. Vershinina, D. R. Nugaeva [et al.] // 15th Annual Conference of the ESC Working Group on Myocardial & Pericardial Diseases (Belgrade, Serbia, 5–7 October 2018).
  13. Clinical polymorphism of RASopathies in children / T. L. Vershinina, O. V. Melnik, A. Y. Gudkova [et al.] // 15th Annual Conference of the ESC Working Group on Myocardial & Pericardial Diseases (Belgrade, Serbia, 5–7 October 2018).
  14. Diagnostic value of cardiac MRI in children with ventricular arrhythmias / T. Loevets, A. Ryzhkov, T. Vershinina [et al.] // ECR 2019 (Vienna, Austria, 27 February — 03 March 2019).
  15. Management of patients with Ebstein's anomaly and accessory pathways / E. S. Vasichkina, T. S. Loevets, K. A. Chueva [et al.] // EHRA 2019 Annual Congress of the European Heart Rhythm Association (Lisbon, Portugal, 17–19 March 2019).
  16. Complex approach to treatment of severe catecholaminergic polymorphic ventricular tachycardia in a 12-years-old boy / T. S. Loevets, D. S. Lebedev, E. S. Vasichkina [et al.] // EHRA 2019 Annual Congress of the European Heart Rhythm Association (Lisbon, Portugal, 17–19 March 2019).
  17. Management of young athletes with ventricular arrhythmias / Yu. Alekseeva, S. V. Popov, I. A. Zemskov [et al.] // EHRA 2019 Annual Congress of the European Heart Rhythm Association (Lisbon, Portugal, 17–19 March 2019).
  18. Disorders of rhythm and conduction in young athletes. Prospective observation data / D. Yu. Alekseeva, S. V. Popov, I. A. Zemskov [et al.] // EHRA 2019 Annual Congress of the European Heart Rhythm Association (Lisbon, Portugal, 17–19 March 2019).
  19. Outcome of arrhythmias in children with suspected myocarditis / E. S. Vasichkina, N. M. Boldina, N. S. Loevets [et al.] // AEPC 2019 (Seville, Spain, 15–18 May 2019).
  20. The approach to drag therapy of arrhythmias in children with suspected myocarditis / T. S. Loevets, E. S. Vasichkina, N. M. Boldina [et al.] // AEPC 2019 (Seville, Spain, 15–18 May 2019).
  21. Radiofrequency ablation of atrial arrhythmias in children: one-centre experience / T. S. Loevets, D. S. Lebedev, E. S. Vasichkina [et al.] // AEPC 2019 (Seville, Spain, 15–18 May 2019).
  22. Dysregulation of Notch signaling in cardiac cell of the patients with tetralogy of Fallot / I. A. Kozyrev, E. S. Vasichkina, T. M. Pervunina [et al.] // AEPC 2019 (Seville, Spain, 15–18 May 2019).
  23. Use of intravenous immunoglobulin in сhildren with inflammatory cardiomyopathy / E. S. Vasichkina, N. M. Boldina, N. S. Loevets [et al.] // AEPC 2019 (Seville, Spain, 15–18 May 2019).
  24. A case of early diagnosis the mucopolysaccharidosis type 1 (Hyrlers syndrome) in 2-month-old girl with acute myocarditis / L. Butish, E. S. Vasichkina, N. S. Loevets [et al.] // AEPC 2019 (Seville, Spain, 15–18 May 2019).
Abstracts in foreign journals
  1. The role of endomyocardial biopsy in establishing the etiology of progressive ventricular arrhythmias in children / E. S. Vasichkina, L. B. Mitrofanova, R. B. Tatarsky [et al.] // Cardiology in the Young. Vol. 27. Suppl. S2. P. S70.
  2. Clinical course of myocarditis complicated by atrioventricular block in young children / E. S. Vasichkina, N. M. Boldina, T. M. Pervunina [et al.] // Cardiology in the Young. Vol. 27. Suppl. S2. P. S77.
  3. Presyncope and syncope events in pediatric patients with paroxysmal supraventricular tachycardia / T. Kruchina, O. Gordeev, I. Pushkareva [et al.] // Europace. 2017. Vol. 19. Suppl. 3. P. iii397 (abstract P1795). EHRA Europace-Cardiostim 2017 (Vienna, Austria, 18–21 June 2017).
  4. Classification and diagnostic features of supraventricular tachycardia in children / T. Kruchina, O. Gordeev, I. Pushkareva [et al.] // Europace. 2017. Vol. 19. Suppl. 3. P. iii397 (abstract P1796). EHRA Europace-Cardiostim 2017 (Vienna, Austria, 18–21 June 2017).
  5. Characteristics and clinical significance of bradycardia in children / T. Kruchina, O. Gordeev, I. Pushkareva [et al.] // Europace. 2017. Vol. 19. Suppl. 3. P. iii397 (abstract P1797). EHRA Europace-Сardiostim 2017 (Vienna, Austria, 18–21 June 2017).
  6. New arrhythmias in pediatric and young patients with antibradycardia pacing / I. Pushkareva, T. Kruchina, A. Adrianov [et al.] // Europace. 2017. Vol. 19. Suppl. 3. P. iii104 (abstract P466). EHRA Europace-Cardiostim 2017 (Vienna, Austria, 18–21 June 2017).
  7. The results of the pharmacological treatment in children with chronic sinus tachycardia and focal atrial tachycardia / I. Pushkareva, T. Kruchina, O. Gordeev [et al.] // Europace. 2017. Vol. 19. Suppl. 3. P. iii225 (abstract P1041). EHRA Europace-Cardiostim 2017 (Vienna, Austria, 18–21 June 2017).
  8. Integrated model for the risk assessment of the unfavourable course of bimodal pathology in children / E. S. Vasichkina, T. M. Pervunina, T. M. Kruchina [et al.] // Cardiology in the Young. Vol. 28. Suppl. S1. P. S70.
  9. Use, effectiveness and safety of Ivabradine in paediatric patients with atrial tachycardia / T. S. Loevets, T. M. Pervunina, L. Butish [et al.] // Cardiology in the Young. Vol. 28. Suppl. S1. P. S70.
  10. Analysis of Notch pathway activity in cardiac progenitor ctlls of the patients with congenital heart defects / I. A. Kozyrev, E. V. Ignatieva, A. S. Golovkin [et al.] // Cardiology in the Young. Vol. 28. Suppl. S1. P. S15.
  11. A rare case of truncus arteriosus with right pulmonary artery arising from brachiocephalic trunk / A. Morozov, E. Grekhov, A. Latypov [et al.] // 26th Annual Meeting of the Asian Society for Cardiovascular and Thoracic Surgery. Abstract book. P. 202-203.
  12. Early primary complete repair in patients with tetralogy of fallot with pulmonary stenosis/pilmonary atresia younger 5 months / I. Kozyrev, A. Latypov, A. Morozov [et al.] // 26th Annual Meeting of the Asian Society for Cardiovascular and Thoracic Surgery. Abstract book. P. 203.
  13. A fatal case of the Barth Syndrome in 1-year-old boy / T. S. Loevets, N. M. Boldina, E. V. Yakovleva [et al.] // European Journal of Heart Failure. Vol. 20, Issue S1. P. 637. Abstracts of the Heart Failure 2018 and the World Congress on Acute Heart Failure.
  14. Tachycardia-induced cardiomyopathy in children / E. Yakovleva, T. S. Loevets, T. L. Vershinina [et al.] // European Journal of Heart Failure. Vol. 20, Issue S1. P. 283. Abstracts of the Heart Failure 2018 and the World Congress on Acute Heart Failure.
  15. Computed tomography angiography in children with low left ventricular ejection fraction / A. Skripnik, V. Fokin, G. E. Trufanov [et al.] // The European Society of Cardiac Radiology – Annual Scientific Meeting 2018 (Geneva, Switzerland 24–26 May 2018). Poster Abstracts: DOI: 10.25649/ESCR.2018.APP.
  16. Outcome of arrhythmias in children with suspected myocarditis / E. S. Vasichkina, N. M. Boldina, N. S. Loevets [et al.] // Cardiology in the Young. Vol. 29, Issue S1. P. S77. (Импакт-фактор 0,978).
  17. The approach to drag therapy of arrhythmias in children with suspected myocarditis / T. S. Loevets, E. S. Vasichkina, N. M. Boldina [et al.] // Cardiology in the Young. Vol. 29, Issue S1. P. S76. (Импакт-фактор 0,978).
  18. Radiofrequency ablation of atrial arrhythmias in children: one-centre experience / T. S. Loevets, D. S. Lebedev, E. S. Vasichkina [et al.] // Cardiology in the Young. Vol. 29, Issue S1. P. S76. (Импактфактор 0,978).
  19. Dysregulation of Notch signaling in cardiac cell of the patients with tetralogy of Fallot / I. A. Kozyrev, E. S. Vasichkina, T. M. Pervunina [et al.] // Cardiology in the Young. Vol. 29, Issue S1. P. S87. (Импакт-фактор 0,978).
  20. Use of intravenous immunoglobulin in children with inflammatory cardiomyopathy / E. S. Vasichkina, N. M. Boldina, N. S. Loevets [et al.] // Cardiology in the Young. Vol. 29, Issue S1. P. S175. (Импакт-фактор 0,978). 
  21. A case of early diagnosis the mucopolysaccharidosis type 1 (Hyrlers syndrome) in 2-month-old girl with acute myocarditis / L. Butish, E. S. Vasichkina, N. S. Loevets [et al.] // Сardiology in the Young. Vol. 29. Issue S1. P. S86. (Импакт-фактор 0,978).