Research Department for CVDs in Children/Research Group for Pediatric Cardiac Surgery

 

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Elena Vasichkina, MD, DSc
Chief Researcher

The Research Department for CVDs in Children/Research Group for Pediatric Cardiac Surgery was established in May 2017.

The activities of the Department relate to basic and applied research aimed at developing and improving methods for the prevention, diagnosis and treatment of cardiovascular disease (CVD) in children.

Major research areas

  • Inflammatory myocardial diseases
  • Cardiomyopathies
  • Congenital and acquired heart defects
  • Molecular and genetic basis of heart rhythm and conduction disorders
  • Etiological and pathomorphological features of progressive heart rhythm and conduction disorders
  • Fetal cardiology and arrhythmology, severe heart failure
  • Management of patients before and after heart transplantation
  • Rehabilitation of patients with heart disease and after surgery for CHD
  • Pulmonary hypertension
  • Syncopal conditions

Participation in State Assignments

Ongoing basic research: “Personalized medicine in choosing a strategy for the diagnosis and treatment of heart failure due to heart remodeling in congenital heart defects, arrhythmias and genetically determined myocardial diseases in children.”

Clinical studies

  • Clinical testing “Use of immunomodulatory therapy in children with inflammatory myocardial diseases” (2015—2018)
  • Clinical testing “Personalized therapy for chronic heart failure in children with cardiomyopathies based on pharmacogenetics using a new generation sequencing technology for genetic verification of the diagnosis” (2016—2017)

Participation in national and international conferences

In the past 3 years, research specialists took part in 14 international congresses with 25 presentations: 51, 52, 53 Annual meeting of the Association for European Paediatric and Congenital Cardiology (29 March-1 April 2017, Lion, France; 9-12 May 2018 Athens, Greece; 15-18 May 2019, Seville, Spain); EHRA Europace-Сardiostim 2017 (18 -21 June 2017, Vienna, Austria); EHRA 2019 (17-19 March 2019 Lisbon, Portugal); 7th World Congress of Pediatric Cardiology and Cardiac Surgery (16-21 July, Barcelona, Spain); ESC Congress 2017 (26-30 August, Barcelona, Spain); 26th Annual Meeting of the Asian Society for Cardiovascular and Thoracic Surgery (24-27 May 2018, Moscow); The World Congress on Acute Heart Failure (26-29 May 2018,Vienna, Austria); 15th Annual Conference of the ESC Working Group on Myocardial & Pericardial Diseases (5-7 October 2018, Belgrade, Serbia); Annual European congress radiology (27-03 March 2019, Vienna, Austria).

They also took part in 40 Russian conferences with 75 presentations.

Membership in national and international societies

The specialists of the Department are members of many Russian and international professional societies including the All-Russian Association of Pediatric Cardiologists, Russian Society of Cardiology, All-Russian Scientific Society of Arrhythmology, European Society of Cardiology (ESC), European Heart Rhythm Association (EHRA) and Heart Failure Association (HFA).

Internships at foreign medical universities

E.S. Vasichkina – Harvard University (Boston Children's Hospital)

E.V. Grekhov – BC Children's Hospital (Vancouver, Canada)

A.A. Morozov – Ochsner Medical Center (New Orleans, USA); The Institut Hospitalier Jacques Cartier (Massy, France); Yale University (Yale-New Haven Hospital, USA)

Training and education

The specialists deliver annual educational cycles for doctors specializing in Pediatric Cardiology, courses on clinical and interventional arrhythmology, severe congenital heart defects (CHD) and myocardial diseases.

Awareness raising activities

The specialists organize and conduct educational sessions for parents of children with heart failure, cardiac arrhythmias, syncope. They take an active part in the annual All-Russian children's festival “Children's Heart Day.”

Competence Centre

The interdisciplinary team of highly skilled specialists, state-of-the-art facilities and innovative solutions provided an excellent ground for the establishment of a Pediatric Cardiology Competence Centre to implement the innovations in the field of pediatric cardiology and cardiac surgery, discover and exchange new knowledge in the diagnosis and treatment.

Clinical practice

All specialists of the Department are highly qualified and board certified cardiac surgeons, cardiologists and pediatricians. The clinical sites are: Department of Cardiovascular Surgery for Children, Department of Pediatric Cardiology and Medical Rehabilitation, Cardiac Intensive Care Unit, Neonatal Disease Unit.

Major publications

In 2017–2020, the specialists published 43 articles in journals indexed by the Higher Attestation Commission, 14 in Scopus, 5 monographs and 2 patents.

Averkin I., Grehov E., Pervunina T., Komlichenko E., Vasichkina E., et.al. 3D-printing in preoperative planning in neonates with complex congenital heart defects. The Journal of Maternal-Fetal & Neonatal Medicine.2020;33 (15). DOI: 10.1080/14767058.2020.1771691. Access link: https://www.tandfonline.com/doi/full/10.1080/14767058.2020.1771691?scroll=top&needAccess=true

Vasichkina, E; Poghosyan, H; Mitrofanova, L; Tatarsky, R; Lebedev, D. Quantification of prospective type 2 diabetes mellitus biomarkers by stable isotope dilution with bi-labeled standard glycated peptides. ANALYTICAL METHODS. 2017;9 (3):409-418. DOI: 10.1039/c6ay02483a. Access link: https://pubs.rsc.org/en/content/articlelanding/2017/ay/c6ay02483a

Vasichkina E., Mitrofanova L., Tatarsky R., Lebedev D., Poghosyan H. Right ventricular endomyocardial biopsy in children and adolescents with drug-refractory arrhythmia. Cardiology in the Young. 2017;27 (3):435-442. DOI: 10.1017/S1047951116000688. Access link: https://pubs.rsc.org/en/content/articlelanding/2017/ay/c6ay02483a

Patents

Patent No. 2687787 issued on 16.05.2019, application No. 2018116793 dated 04.05.2018
«Method of surgical treatment of coarctation of the aorta with distal arch hypoplasia»
Authors: E.V. Grekhov, A.A. Ivanov

Patent No. 2611904 issued on 01.03.17, priority certificate No. 2015145910 dated 26.10.15
«Treatment method for non-coronary ventricular arrhythmias by radiofrequency catheter ablation of diastolic potentials»
Authors: R.B. Tatarsky, D.S. Lebedev, E.S. Vasichkina, V.A. Rodionov, V.P. Gorelov