Research Laboratory for Physiology and Diseases of Newborns

 
Natalya Petrova, MD, PhD
Head of Laboratory

The Research Laboratory for Physiology and Diseases of Newborns has been operational since 2012.

The specialists of the Laboratory act as consulting doctors at the neonatal physiology department, pediatric intensive care unit, departments for diseases in newborns and premature infants and for pediatric surgery of birth defects.

The Laboratory supervises the organization of care at the Children's Rehabilitation Clinic for children with sleep-disordered breathing, including congenital hypoventilation syndromes, ROHHAD syndrome, children with chronic lung diseases requiring home ventilation, and provides telemedicine consultations.

Major areas

  • Studying the underlying mechanisms of intrauterine growth restriction (IUGR) and the development of these mechanisms in the postnatal period in the form of an increased risk of cardiovascular and endocrine diseases.
  • Studying the role of insulin-like growth factors GH, IGF-1, IGF-2, IGFBP-3 and insulin in the formation of metabolic and endocrine disorders in children with IUGR
  • Studying the cellular mechanisms of systemic diseases in children with IUGR syndrome

Ongoing research

  • Basic research aimed at studying the epigenetic and microbiome mechanisms of neonatal necrotizing enterocolitis in order to identify predictors, develop new preventive and treatment strategies.
  • Participation in the “Development of an experimental model for the treatment of bronchopulmonary dysplasia in preterm infants using mesenchymal stem cells” jointly with the Institute of Molecular Biology and Genetics.

Participation in multicenter international studies

  • Open-label multi-part first-in-human study of oral LMI070 in infants with spinal muscular atrophy (SMA) type I.
  • Phase 2/3 randomized, double-blind, palivizumab-controlled study to evaluate the safety of MEDI8897, a monoclonal antibody with an extended half-life against respiratory syncytial virus, in high-risk children (MEDLEY).

Awards and achievements

In 2018, the programme “Rehabilitation in children with congenital central alveolar hypoventilation syndrome (CCHS)” developed at the Children's Rehabilitation Clinic of Almazov Centre won the top All-Russian award of the Russian Association of Perinatal Medicine Specialists.

Training and education

In 2013, the specialists of the Laboratory trained 72 neonatologists on the cycles “Neonatal intensive care with skills training in the simulation centre” (72 hours).

The specialists also conduct primary retraining (504 hours) and advanced training cycles (144 hours, 288 hours) in «Neonatology» at the Perinatal Centre for doctors from all Russian regions.

The specialists of the Laboratory act as attending and consulting doctors at the departments and units of the Perinatal Centre.

Conferences

XIII World Congress of Perinatal Medicine, Belgrade, October 26-29, 2017

Kristina Islamova, Dmitriy Ivanov, Yuriy Petrenko, Natalia Petrova, Tatyana Fedoseeva. HORMONAL ASPECTS OF POSTNATAL GROWTH FROM BIRTH TO AGE OF SIX MONTHS IN INFANTS WITH ASYMMETRICAL AND SYMMETRICAL INTRAUTERINE GROWTH RETARDATION

XXVI European Congress of Perinatal Medicine, St-Petersburg, Russia, 5-8 September, 2018
K. Islamova; N. Petrova; E. Kazakova; D. Ivanov; Yu. Petrenko. The role of the type of intrauterine growth restriction in the changes of “growth hormone – insulin-like growth factor-1” axis and insulin sensitivity in infants from birth to the age of six months.

IPSA 2018 — 5th International Paediatric Sleep Association Congress, April 27-29, 2018, Paris, France
Natalia Petrova, Grigory Rubin, Dmitry Gorshkov, Dmitry Novoseltsev, Natalia Kolbina, Galina Obraszova.  Noninvasive ventilation experience in three Russian infants with congenital central hypoventilation syndrome

5th International CCHS conference. June, 20-23, 2018, St. Louis, USA
N. Petrova. Congenital central hypoventilation syndrome in Russian Federation – current data.

Saint Petersburg Sleep Congress 2019
Congenital central hypoventilation syndrome in Russian Federation – current data