Research Laboratory of Reproduction and Women's Health

 
Lyubov Kuznetsova, MD, PhD
Head of Laboratory

Focus areas:

  • Role of endothelial factors in preeclampsia development. Search of early preeclampsia biochemical markers.
  • Role of vitamin D deficiency in perinatal conditions. Calcium-phosphorus metabolism during pregnancy and lactation, methods of its correction to prevent complications in mothers and newborns. Vitamin D deficiency in the pathogenesis of miscarriage.
  • Role of uterine artery embolization in the prevention of obstetric complications and treatment of gynecological diseases.
  • Possibility of using hormonal contraception in women with cardiac and endocrine disorders.
  • Menopausal disorders and their correction in patients with cardiac and endocrine diseases. Changes in the elastic properties of blood vessels in menopausal women and correction of menopausal disorders. The role of vitamin D deficiency in postmenopausal osteopenia.
  • Functional changes of the vascular wall during normal and at-risk pregnancy.

Participation in the clinical testing of new treatments

New approaches to the diagnosis and treatment of placenta previa and accreta using endovascular techniques.

International collaboration:

Research projects are carried out jointly with the National Institutes of Aging, National Institutes of Health (Baltimore, Maryland, United States).

In the framework of the international exchange of experience between Almazov Centre and the Karolinska Institute (Sweden), the specialists of the Centre won the grant for internships at the Karolinska Institute on the topic “Surgical treatment of twin-to-twin syndrome” and “Vascular wall changes during pregnancy.”

Каролинский ин-т-3_0 Каролинский ин-т-2_0 Каролинский ин-т-1_0

Training and education

Over 2017 to 2018:

  • 17 CPE courses of 36-72 hours, including 10 simulation cycles.
  • 2 certification cycles of 144 hours.

197 doctors from 27 regions of Russia were trained.

CPE cycles and modules:

  • Obstetrics and gynecology (certification) (144 hours)
  • Somatic disease and pregnancy (36 hours)
  • Laparoscopy in gynecology (simulation) (72 hours)
  • Clinical obstetrics (simulation) (72 hours)
  • Emergency conditions in obstetrics (36 hours)
  • Oncogynecology (18 hours)
  • Hemostatic disorders in obstetrics: from bleeding to thrombosis (36 hours)
  • Selected issues of gynecological endocrinology (by modules):

— miscarriage and premature delivery;

— endocrine aspects of reproductive health;

— menopausal problems.

Workshops:

  • Gestational Diabetes Mellitus in the framework of the International Congress «Major obstetric and neonatal syndromes — pathology and clinical practice», St. Petersburg, 2017.
  • Medicines for Pregnancy at the 11th Interdisciplinary Conference on Obstetrics, Perinatology, Neonatology, Healthy Woman – Healthy Newborn, St. Petersburg, 2018.
  • Menopause, St. Petersburg, 2018.
  • Topical Issues of Hemostatic Disorders in Obstetric Practice at the 4th All-Russian conference with international participation Perinatal Medicine: From Preconception to Healthy Motherhood and Childhood, St. Petersburg, 2018.
Participation in conferences (2017–2019)
  • 3rd All-Russian conference with international participation, Perinatal Medicine: From Preconception to Healthy Motherhood and Childhood, St. Petersburg, 2017.
  • Scientific and practical conference Reproductive Health of the Family, Chelyabinsk, 2017.
  • 2nd All-Russian seminar, Reproductive Potential of Russia: Versions and Controversies, Moscow, 2017.
  • Workshop on Gynecological Endocrinology for Obstetricians and Gynecologists, St. Petersburg, 2017.
  • 10th Interdisciplinary Conference on Obstetrics, Perinatology, Neonatology, Healthy Woman – Healthy Newborn, St. Petersburg, 2017.
  • Regional scientific and practical workshop, Topical Issues of Obstetrics and Gynecology in the Northwestern Federal District, Kaliningrad, 2017.
  • 17th World Congress of the Academy of Human Reproduction, Rome, Italy, 2017.
  • 4th All-Russian conference with international participation, Perinatal Medicine: From Preconception to Healthy Motherhood and Childhood, St. Petersburg, 2018.
  • The 18th World Congress Gynecological Endocrinology, Florence, Italy, 2018.
  • 11th Interdisciplinary Conference on Obstetrics, Perinatology, Neonatology, Healthy Woman – Healthy Newborn, St. Petersburg, 2018.
  • All-Russian scientific and practical conference with international participation, Topical Issues of Modern Endocrinology: Regional Focus, St. Petersburg, 2018.
  • 26th European Congress of Perinatal Medicine (ECPM 2018), St. Petersburg, 2018.
  • 10th International DIP Symposium on Diabetes, Hypertension, Metabolic Syndrome & Pregnancy, 29 May – 1 June 2019, Florence, Italy.
  • 5th All-Russian conference with international participation, Perinatal Medicine: From Preconception to Healthy Motherhood and Childhood, St. Petersburg, 2019.
  • All-Russian conference with international participation, Patient-Oriented Technologies in Perinatology and Pediatrics, St. Petersburg, 2019

Major publications

Magnesium sulfate potentiates effect of digifab on arinobufagenin-induced Na/K-ATPase inhibition / I. Zazerskaya, V. Ishkaraeva, E. Frolova [et al.] // American Journal of Hypertension. Vol. 26 (11). P. 1269–1272.

The prevalence of vitamin D deficiency in women with infertility and miscarriage / I. Zazerskaya, V. Korsak, L. Shirinyan [et al.] // 16th World Congress of Gynecological Endocrinology, 2014.

Shirinyan L., Novikova T., Zazerskaya I. Dependence of the saturation of the organism with vitamin D on serum concentration of 25- (OH) -D during pregnancy // 16th World Congress of Gynecological Endocrinology, 2014.

Shelepova E., Zazerskaya I. Correlation between biochemical parameters of the bone metabolism and vitamin D level during pregnancy // 16th World Congress of Gynecological Endocrinology, 2014.

Novikova T., Zazerskaya I. Distribution of bone mineral density by different parts of skeleton in parturients with different levels of vitamin D // 16th World Congress of Gynecological Endocrinology, 2014.

Kuznetsova L.V. Factors affecting the effectiveness of therapy of osteopenic syndrome in postmenopausal women // Materials of gynecological endocrinology: the 18th world congress, 2018.

Individual approach to reduction of the risk of somatic pathology in postmenopausal women using MHT / Ya. V. Kostroma, L.V. Kuznetsova, I.E. Zazerskaya [et al.] // Materials of gynecological endocrinology: the 18th World Congress, 2018.

Khazova E.L., Kuznetsova L.V., Shelepova E.S. Two seasons of the level of calcidiol in pregnant women of St. Petersburg // Materials of gynecological endocrinology: the 18th World Congress, 2018.

Vitamin D deficiency and pregnancy outcome / I.E. Zazerskaya, E.L. Khazova, E.S. Shelepova [et al.] // Materials of gynecological endocrinology: the 18th World Congress, 2018.

Novikova T.V. Obstetric-gynecological risk factors for osteopenia in the postpartum period // Materials of gynecological endocrinology: the 18th World Congress, 2018.

Ishkaraeva V.V. Antibody to marinobufagenin reverses placenta-induced fibrosis of umbilical arteries in preeclampsia // J. Mol. Sci. 2018. Vol. 19. P. 2377.

New highly sensitive sandwich ELISA system for soluble endoglin quantification in different biological fluids / I. V. Smirnov, I. V. Gryazeva, M. Y. Vasileva [et al.] // Scand J Clin Lab Invest. 2018. Oct 1. P. 1–9. DOI: 10.1080/00365513.2018.1516892.

Antibody to marinobufagenin reverses placenta-induced fibrosis of umbilical arteries in preeclampsia / O. V. Fedorova, V. V. Ishkaraeva, Y. N. Grigorova [et al.] // Int J Mol Sci. 2018. Aug Vol. 19 (8). DOI: 10.3390/ijms19082377.