Pathology Unit

 

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Lubov Mitrofanova, MD, DSc
Head of Pathology Unit, Chief Researcher, Associate Professor

Major objectives

  • Studies on the cardiac conduction system at the macroscopic (layer-by-layer dissection, organometry), histological (layered serial histological sections), histochemical, immunohistochemical and ultrastructural levels
  • Morphology, etiology and pathogenesis of atrial fibrillation with morphometric, immunohistochemical studies
  • Arrhythmogenic right ventricular dysplasia with morphometric, immunohistochemical studies and objectification of differential diagnosis
  • Etiology and pathogenesis of myocarditis with studies on the broad spectrum of cardiotropic viruses
  • Etiology and pathogenesis of acquired valvular heart disease
  • Congenital cardiomyopathy with a full range of histochemical and immunohistochemical reactions to detect cardiomyocyte proteins
  • Sudden cardiovascular death
  • Vasculitis
  • Heart tumors
  • Studies of endomyocardial biopsy in various diseases and heart transplant

Research areas

  • Morphological and genetic study of adult gliomas to clarify the diagnosis and create new directions of targeted therapy.
  • Morphological study of the pancreas in children under one year old with and without congenital hyperinsulinism to clarify the diagnosis and create new directions of targeted therapy.
  • Study of immunophenotypes and features of perivascular innervation of the pulmonary artery in humans and in animal experiments to develop new treatments for pulmonary hypertension.
  • Study of telocytes in normal and diseased heart and brain as candidates for the role of an interstitial stem cell – pericyte or telocyte
  • Morphological study of neuroendocrine tumors to improve and develop new drugs for targeted therapy
Newly developed and implemented technologies

Confocal laser microscopy of the functional left atrial myocardium in a patient without atrial fibrillation with a mixture of CD34 / S100.

комфокальная лазерная микроскопия

Electronic transmission microscopy. Left atrial myocardium in a patient with rheumatic mitral valve disease and long-term atrial fibrillation.

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Adenomatous form of congenital hyperinsulinism. Insulin expression in the pancreas.

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Development of a new method for the diagnosis and treatment of pulmonary hypertension by mapping the neural structures of the pulmonary artery with high-frequency stimulation and three-dimensional navigation mapping.

News

Almazov Centre is developing a new method to diagnose and treat pulmonary hypertension

Participation in State Assignments

  • Study of morphological and electrophysiological properties of sinus node and myocardial telocytes for diagnosis and cell therapy of arrhythmias (2018—2021). Supervised by L. Mitrofanova.

Grants

  • Method for studying neurogenic regulation of the pulmonary circulation and remodeling of the pulmonary artery and substantiation of a new method for treating pulmonary hypertension by selective effect on neural elements (supervised by E. Mikhailov). Completion date: 01.10.2020.

Specialists of the Pathology Unit are contributors to the grant.

International collaboration

  • Department of Cardiology Lund University Hospital, Sweden
  • Royal Brompton Hospital and Imperial College, London, United Kingdom
  • Department of Neuropathology, Medical Center, Johannes Gutenberg University, Mainz, Germany
  • Hospital de Hautepierre, Strasbourg, France
  • Universita Vita-Salute San Raffaele, Milano, Italy
  • Deutsches Herzzentrum, Berlin, Germany
  • German Heart Institute, Berlin, Germany
Major publications

Mitrofanova L,  Hazratov A, Galkovsky B, Gorshkov A, Bobkov D, Gulyaev D, Shlyakhto E. Morphological and immunophenotypic characterization of perivascular interstitial cells in human glioma: telocytes, pericytes, and mixed immunophenotypes. 2020;11 (4):322-346. doi: 10.18632/oncotarget.27340

Mitrofanova, L.B., Vorobeva, O.M., Gorshkov, A.N. Analysis of pituitary adenoma expression patterns suggests a potential role for the NeuroD1 transcription factor in neuroendocrine tumor-targeting therapies. 2019; 10 (3): 289-312. DOI: 10.18632/oncotarget.26513. Q1; (Scopus)

Kudryavtsev, I; Serebriakova, M; Zhiduleva, E; Murtazalieva, P; Titov, V; Malashicheva, A; Shishkova, A; Semenova, D; Irtyuga, O; Isakov, D; Mitrofanova, L; Moiseeva, O; Golovkin, A. CD73 Rather Than CD39 Is Mainly Involved in Controlling Purinergic Signaling in Calcified Aortic Valve Disease. FRONTIERS IN GENETICS. 2019; 10: ID 604 (эл.ресурс). DOI: 10.3389/fgene.2019.00604. Q1; (Scopus и Web of Science)

Kiselev, A; Vaz, R; Knyazeva, A; Sergushichev, A; Dmitrieva, R; Khudiakov, A; Jorholt, J; Smolina, N; Sukhareva, K; Fomicheva, Y; Mikhaylov, E; Mitrofanova, L; Predeusu, A; Sjoberg, G; Rudenko, D; Sejersen, T; Lindstrand, A; Kostareva, A. Truncating Variant in Myof Gene Is Associated With Limb-Girdle Type Muscular Dystrophy and Cardiomyopathy. FRONTIERS IN GENETICS. 2019; 10: ID 608 (эл.ресурс). DOI: 10.3389/fgene.2019.00608. Q1; (Scopus и Web of Science)

Mitrofanova, LB; Gorshkov, AN; Konovalov, PV; Krylova, JS. Telocytes in the human sinoatrial node. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2018; 22 (1): 521-532. DOI: 10.1111/jcmm.13340. Q1; (Scopus и Web of Science)

Mitrofanova, LB; Konovalov, PV; Krylova, JS; Polyakova, VO; Kvetnoy, IM. Plurihormonal cells of normal anterior pituitary: Facts and conclusions. 2017; 8 (17): 29282-29299. DOI:10.18632/oncotarget.16502. Q1; (Scopus и Web of Science)

Basso, C; Aguilera, B; Banner, J; Cohle, S; d'Amati, G; de Gouveia, RH; di Gioia, C; Fabre, A; Gallagher, PJ; Leone, O; Lucena, J; Mitrofanova, L; Molina, P; Parsons, S; Rizzo, S; Sheppard, MN; Mier, MPS; Suvarna, SK; Thiene, G; van der Wal, A; Vink, A; Michaud, K. Comparison of heart rate in embryonic, young and adult Achatina fulica. MOLLUSCAN RESEARCH 2017; 37 (2):133-139. DOI: 10.1080/13235818.2016.1242185. Q2; (Scopus и Web of Science)

Vasichkina, E; Poghosyan, H; Mitrofanova, L; Tatarsky, R; Lebedev, D. Quantification of prospective type 2 diabetes mellitus biomarkers by stable isotope dilution with bi-labeled standard glycated peptides. ANALYTICAL METHODS. 2017; 9 (3): 409-418. DOI: 10.1039/c6ay02483a. Q1; (Scopus и Web of Science)

Patents and inventions

Patent No. 2364370, “Method for interventional treatment of paroxysmal atrial fibrillation”
Authors: D.S. Lebedev, E.N. Mikhailov, L.B. Mitrofanova, S.V. Gureev

Patent. No. 2336528, “Method for predicting early postoperative complications in patients with rheumatic heart disease”
Authors: L.B. Mitrofanova, A.G. Kudaibergenova, E.P. Ivanova, E.V. Nemchenko

Patent No. 2308229, “Method for diagnosing the suitability of the radial artery for use as a conduit in coronary artery bypass grafting”
Authors: M.L. Gordeev, E.P. Ivanova, E.V. Kuleshova, L.B. Mitrofanova, T.N. Enkina, S.V. Lyutynsky

Patent. No. 2361521, “Method for choosing the type of repair of mitral valve insufficiency”
Authors: E.V. Nemchenko, L.B. Mitrofanova

Patent for invention RU 2718288 C1, “Method for predicting the rate of development of fibrosis in patients with chronic viral hepatitis C”
Authors: D.Yu. Lobzin, S.G. Grigoriev, K.V. Zhdanov, V.E. Karev, G.G. Zagorodnikov, K.V. Kozlov, S.S. Karyakin

Patent for invention RU 2684195 C1, “Method for percutaneous aspiration puncture biopsy of the liver in rats”
Authors: A.V. Saulevich, K.V. Zhdanov, V.E. Karev, S.M. Zakharenko, D.M. Shakhmanov, K.V. Kozlov, Yu.F. Zakharkiv, S.S. Kozlov, V.Yu. Kravtsov, V.S. Sukachev, D.V. Popov, S.S. Karyakin, I.A. Gabdrakhmanov, M.V. Yaremenko, R.V. Gudkov, I.O. Bulavenko, V.S. Turitsin

Patent for invention RU 2695292 C1, “Method of postmortal morphological diagnosis of cerebral edema in neuroinfectious diseases in children”
Authors: V.E. Karev, A.A. Vilnits, N.V. Skripchenko

Patent for invention RU 2706699 C1, “Method for predicting an unfavorable course of liver fibrosis in chronic hepatitis C”
Authors: V.E. Karev, I.A. Karabak, Yu.V. Lobzin

Contacts:
Lubov Mitrofanova, Head of Pathology Unit, Chief Researcher
E-mail: lubamitr@yandex.ru